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Active clinical trials for "Liver Cirrhosis, Biliary"

Results 41-50 of 157

sCD163 in PBC Patients - Assessment of Disease Severity and Prognosis

Primary Biliary CirrhosisLiver Inflammation

Primary biliary cholangitis (PBC) is an autoimmune chronic liver disease, characterised by destruction of the small intrahepatic bile ducts. sCD163 is a macrophage activation marker shedded into plasma by macrophages in the liver. sMR is a soluble mannose receptor. The investigators want to investigate whether sCD163 and sMR correlate with disease severity in patients with PBC, and whether sCD163 and sMR can predict short term disease progression, changes in quality of life and death in these patients.

Active6 enrollment criteria

IBAT Inhibitor A4250 for Cholestatic Pruritus

Biliary CirrhosisPrimary

This study will evaluate the safety, tolerability and influence on itching, bile acids and liver enzyme changes in patients with PBC (Primary Biliary Cirrhosis) treated with A4250

Terminated16 enrollment criteria

A Study of Baricitinib (LY3009104) in Participants With Primary Biliary Cholangitis Who do Not Respond...

Primary Biliary Cholangitis

This study evaluates the safety and efficacy of baricitinib in participants with primary biliary cholangitis (PBC) who do not respond or are unable to take ursodeoxycholic acid (UDCA).

Terminated49 enrollment criteria

Study to Evaluate the Safety and Efficacy of Oral CR845 (Difelikefalin) in Patients With Primary...

Cholestatic Pruritus

This is a multicenter, randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of twice-daily (BID) oral CR845 1.0 mg in patients with PBC with moderate-to-severe pruritus. The study includes a 16-week Treatment Period.

Terminated16 enrollment criteria

Phase 4 Study of Obeticholic Acid Evaluating Clinical Outcomes in Patients With Primary Biliary...

Liver CirrhosisBiliary

Primary Biliary Cholangitis (PBC) is a serious, life-threatening, bile acid related liver disease of unknown cause. Without treatment, it frequently progresses to liver fibrosis and eventual cirrhosis requiring liver transplantation or resulting in death. The investigational drug, Obeticholic Acid (OCA) is a modified bile acid and FXR agonist that is derived from the primary human bile acid chenodeoxycholic acid. The key mechanisms of action of OCA, including its choleretic, anti-inflammatory, and anti-fibrotic properties, underlie its hepatoprotective effects and result in attenuation of injury and improved liver function in a cholestatic liver disease such as PBC. The study will assess the effect of OCA compared to placebo, combined with stable standard care, on clinical outcomes in PBC participants.

Terminated37 enrollment criteria

Non-comparative Study of BCD-085 in Combination With UDCA in Patients With Primary Biliary Cholangitis...

Liver CirrhosisBiliary

BCD-085 is an innovative drug, anti-interleukin-17 monoclonal antibody. The aim of the study is to evaluate the efficacy and safety of BCD-085 in patients with primary biliary cholangitis (PBC).

Terminated27 enrollment criteria

EXerCise Intervention in cholesTatic LivEr Disease: The EXCITED Study

Primary Biliary Cholangitis

A prospective, single centre, single-arm, pilot study investigating the safety and efficacy of a 12-week remotely-monitored home-based exercise program in patients with refractory fatigue (based on PBC-40 Quality of Life measure) secondary to Primary Biliary Cirrhosis.

Terminated16 enrollment criteria

Study to Evaluate the Safety, Tolerability, and Efficacy of Cilofexor in Adults With Primary Biliary...

Primary Biliary Cholangitis

The primary objective of this study is to evaluate the safety and tolerability of cilofexor in adults with primary biliary cholangitis (PBC).

Terminated20 enrollment criteria

BRIDGE Device for Post-operative Pain Control

Liver FailureLiver Diseases8 more

Auricular neurostimulation is a potential novel and non-invasive method of pain control following liver transplantation in a growing patient population with the probability of significant impact on economics and morbidity. The investigators propose a pilot study to investigate the effects of auricular neurostimulation in patients receiving a liver transplantation. The investigator will investigate the effects of auricular neurostimulation with this novel device and compare it to the current standard of care for pain management following liver transplantation.

Terminated13 enrollment criteria

Study of Obeticholic Acid (OCA) Evaluating Pharmacokinetics and Safety in Participants With Primary...

Liver CirrhosisBiliary

This Phase 4, randomized, double-blind, placebo-controlled study will evaluate the pharmacokinetics (PK) and safety of OCA treatment in participants with PBC and moderate to severe hepatic impairment over a 48-week treatment period. Participants who have completed their 48-week double blind treatment period will continue double-blind treatment until all randomized participants have completed their 48-week treatment period and the database for that period is locked. An open-label extension study in which all participants receive OCA will be considered following review of blinded safety and PK data.

Terminated30 enrollment criteria
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