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Active clinical trials for "Pulmonary Emphysema"

Results 71-80 of 198

Safety and Clinical Outcomes Study: SVF Deployment for Orthopedic, Neurologic, Urologic, and Cardio-pulmonary...

Neurodegenerative DiseasesOsteoarthritis4 more

To evaluate for any adverse effects that may be related to the administration and reception of autologous adipose derived stromal vascular fraction (SVF). Secondarily, the study monitors the results of subjective and objective findings as it applies to the non-blinded deployment of autologous SVF for various inflammatory and/or degenerative conditions including select orthopedic, neurologic, urologic and cardio-pulmonary conditions. SVF deployments include intra-venous, intra-articular, and soft tissue injections.

Completed5 enrollment criteria

Improving Patient Outcomes by Selective Implantation of the Zephyr EBV - Study

COPD Patients With Homogeneous EmphysemaEndoscopic Lung Volume Reduction With Endobronchial Valve

The aim of this prospective, randomized, controlled, one-way crossover study is to assess and compare the efficacy of the Zephyr endobronchial valves vs. Standard of Care (SoC) in patients suffering from COPD with Homogeneous Emphysema. Patients will be followed up for 12 months after randomization. Patients in the SoC arm will crossover to the EBV treatment arm after the 6-month visit and will be followed up for 6 additional months.The primary objective is the variation of FEV1 between baseline and 3-month follow-up visit. The secondary objectives will evaluate quality of life, exercise capacity, dyspnea (including BODE index) changes, target lobe volume reduction, as well as safety outcomes.

Completed20 enrollment criteria

Evaluation of Physiologic Parameters to Study the Mechanism of Action of the Lung Volume Reduction...

Emphysema

The PneumRx Lung Volume Reduction Coil (LVRC) has been shown to effectively improve quality of life, exercise capacity, and static lung volumes, in patients with emphysema. The mechanism of action for these effects is believed to be related to the restoration of elastic recoil to lung parenchyma that has been damaged by emphysema. The objective of this study is to evaluate several physiologic parameters which should provide measures directly related to the mechanism of action by which the coils produce these outcomes.

Completed2 enrollment criteria

AeriSeal® System for Lung Volume Reduction in Patients With Advanced Emphysema

Pulmonary EmphysemaCOPD1 more

The purpose of this study is to assess the procedural and post-procedural safety and efficacy of AeriSeal therapy at up to 4 subsegments during a single treatment session in patients with GOLD Stage III/IV homogeneous or heterogeneous emphysema.

Completed4 enrollment criteria

Israeli Biologic Lung Volume Reduction (BLVR) Phase 1 Emphysema Study

Pulmonary EmphysemaChronic Obstructive Pulmonary Disease

The purpose of this study is to evaluate the safety and efficacy of the Biologic Lung Volume Reduction System (BLVR) for patients with advanced emphysema refractory to medical therapy.

Completed15 enrollment criteria

TESRA: (Treatment of Emphysema With a Gamma-Selective Retinoid Agonist)

Emphysema

This 2 arm study will investigate the efficacy, safety and tolerability of RAR Gamma versus placebo in ex-smokers with moderate or severe emphysema treated with optimal COPD therapy. Following optimization of COPD therapy (up to 6 weeks) patients will be randomized to receive either RAR Gamma (5mg) or placebo once daily using a 2:1 ratio (active:placebo), in addition to their standard therapy. Following the double-blind treatment period, patients will enter a 4-week follow-up period. The anticipated time on study period is 1-2 years, and the target sample size is 100-500 individuals.

Completed8 enrollment criteria

Endobronchial Valve for Emphysema Palliation Trial (VENT)

Chronic Obstructive Pulmonary DiseaseEmphysema

The purpose of this study is to assess the safety and efficacy of the Emphasys Endobronchial Valve (EBV) and procedure (with pulmonary rehabilitation) compared to optimal medical management (with pulmonary rehabilitation) in patients with heterogeneous emphysema.

Completed11 enrollment criteria

Innovation in Pulmonary Rehabilitation

Pulmonary DiseasePulmonary Emphysema

The purpose of this study was to compare the effect of exercise treatment combined with breathing retraining (a computerized feedback program), with exercise treatment combined with heliox (a helium and oxygen combination), with exercise only in patients with moderate to severe chronic obstructive pulmonary disease. This was an 8-week intervention study.

Completed10 enrollment criteria

National Emphysema Treatment Trial (NETT)

EmphysemaLung Diseases3 more

To evaluate the long term efficacy, morbidity and mortality associated with medical therapy with lung volume reduction surgery (LVRS) as compared to medical therapy alone and to define patient selection criteria. The trial, conducted in conjunction with a patient registry, is supported by the NHLBI, the Centers for Medicare and Medicaid Services (CMS), and the Agency for Healthcare Research and Quality (AHRQ).

Completed1 enrollment criteria

Feasibility of Retinoic Acid Treatment in Emphysema (FORTE)

EmphysemaLung Diseases3 more

To conduct feasibility studies on the use of retinoids in the treatment of emphysema. Specific objectives are to identify optimal patient populations, retinoids, doses, dosing schedules, routes of administration, and outcome measures preparatory to conducting a larger, controlled, clinical trial on the efficacy of retinoid therapy in the management of emphysema.

Completed7 enrollment criteria
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