
Auto-PAP for Pulmonary Hypertension Treatment in Decompensated HF Patients With Sleep Apnea.
Sleep ApneaObstructive3 moreThe objective of the study is to evaluate the effect of continuous positive airway pressure (PAP) therapy on pulmonary arterial (PA) pressures in acute decompensated heart failure (HF) patients with obstructive sleep apnea (OSA). The study will also assess changes in functional parameters, biomarkers, and echocardiographic parameters.

PDEI Following Mitral Valve Surgery in Patients With Pulmonary Hypertension
Pulmonary HypertensionMitral Valve SurgeryA randomized, placebo controlled, single center clinical trial for evaluation of efficacy and safety of Sildenafil administration in the cardiac ICU following Mitral Valve (MV) Surgery in patients with pre-operative Significant Pulmonary Hypertension.

Remodulin as Add-on Therapy for the Treatment of Persistent Pulmonary Hypertension of the Newborn...
Persistent Pulmonary Hypertension of the NewbornThis pilot study aims to assess the safety and treatment effect of acute dosing with IV Remodulin in neonates with persistent pulmonary hypertension of the newborn (PPHN).

A Dose Escalation Study to Assess the Safety and Efficacy of Pulsed Inhaled Nitric Oxide in Subjects...
Pulmonary HypertensionPulmonary Fibrosis2 moreA phase 2b, open label study to assess the safety and efficacy of increasing doses of pulsed, inhaled nitric oxide (iNO) in subjects with pulmonary fibrosis and sarcoidosis on long term oxygen therapy followed by a long term extension study

Hemodynamic Evaluation of Levosimendan in Patients With PH-HFpEF
Hypertension Pulmonary SecondaryHeart Failure2 morePhase 2 study to evaluate the efficacy and safety of intermittent levosimendan compared with placebo in hemodynamic improvement with exercise in PH-HFpEF subjects

Spironolactone Therapy in Chronic Stable Right HF Trial
Chronic Right-Sided Heart FailurePulmonary Arterial Hypertension10 moreThe purpose of this study is to evaluate the safety, tolerability and mechanistic effects of spironolactone, an aldosterone receptor antagonist, on sympathetic nervous system activity and right heart function and remodeling in patients with chronic right heart failure.

Inspiratory Muscle Training in Pulmonary Hypertension
Pulmonary HypertensionThe aim of this study is to investigate the effective of inspiratory muscle training on respiratory function, exercise capacity, physical activity and quality of life.

Investigation of the Safety and Pharmacology of Dry Powder Inhalation of Treprostinil
Primary Pulmonary HypertensionThe primary objective of this study is to evaluate the long-term safety and tolerability of LIQ861, a dry powder formulation of treprostinil, in patients with Pulmonary Arterial Hypertension (PAH). A secondary objective of this study is to evaluate the comparative bioavailability of treprostinil between two formulations of inhaled therapy.

Effects of Normobaric Hypoxia During Exercise in Patients With Pulmonary Hypertension Receiving...
HypertensionPulmonaryTo study the effect of acute normobaric hypoxia during exercise in patients with pulmonary hypertension with/without Sildenafil

Acute Effects of Inorganic Nitrite on Cardiovascular Hemodynamics in Heart Failure With Preserved...
Heart DiseaseHeart Failure With Preserved Ejection Fraction2 moreHeart failure with preserved ejection fraction (HFpEF) is a major public health problem that has no proven effective treatment. This study assessed the effects of acute nitrite administration on resting and exercise hemodynamics in patients with HFpEF.