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Active clinical trials for "Sarcoma"

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Expanded Access of Vigil in Solid Tumors

Solid TumorEwing Sarcoma6 more

This is an expanded access study involving an investigational product named Vigil. Vigil is considered immunotherapy. Patients who participated in another clinical trial sponsored by Gradalis, and had Vigil made from their tumor tissue removed from a standard operation, however failed the criteria to enroll in the other clinical trial to receive Vigil are eligible to screen for this expanded access trial to receive the Vigil made from their cancer cells. In this study, eligible participants will receive intradermal (under the skin) injections of Vigil, once every 4 weeks (28 days) for 1-12 doses, depending on the number of doses that was made from the cancer cells and if the participant is clinically stable. During the treatment portion of the study, in addition to receiving Vigil injections, participants will also have a physical exam, blood collection for routine and research tests, and assessment of medications, adverse events, and performance status information will be collected. Radiological tumor assessments will be performed every 3 months from Cycle 1. Once treatment ends, participants will continue to be seen in the clinic every 3 months for similar assessments until disease progression occurs. After disease progression, participants will be contacted by phone 4 times a year to determine post study treatment and survival status information.

Temporarily not available22 enrollment criteria

The Prognostic Value of Serum Biomarkers in Ewing's Sarcoma

SarcomaEwing

Extraction of laboratory data from blood tests prior to surgical and chemotherapy and other histological, clinical and instrumental data related to the patient's history from the digitized medical Digitized medical records and analysis of the same. The medical records of 1000 patients from January 1, 2000, until December 31, 2020

Completed5 enrollment criteria

Catequentinib in Patients Who Have Completed an Advenchen Study (A Compassionate Use Trial)

Sarcoma,Soft TissueGynecologic Cancer

Catequentinib (AL3818, Anlotinib) has been developed in a variety of clinical studies as single agents or in combination with others. This trial is designed to offer patients who completed an Advenchen sponsored AL3818 related study without progression the opportunity to continue to receive this investigational product in this Post-Trial Access study (a compassionate use trial), if the Investigator believes the patients can benefit from such a treatment and the patients have signed the Informed Consent Form.

Available7 enrollment criteria

Analysis of the Molecular Profile of the Mixofibrosarcoma of the Extremities

Sarcoma,Soft Tissue

Single institution case series review with a histological diagnosis of mixofibrosarcoma of the extremities from 01 Jan 1993 to 01 Dec 2017. The study will exam all the clinical, radiological, histological and immunohistochemical features of this tumour in all samples and in a limited serie of cases the presence of mutation of 50 genes cancer related.

Completed7 enrollment criteria

Molecular Profiling to Improve Outcome of Patients in Cancer. A Pilot Study

Colorectal CarcinomaSoft Tissue Sarcoma

Next Generation Sequencing in cancer: a feasibility study in France to assess sample circuit and to perform analyzes within a limited time.

Completed5 enrollment criteria

Outcomes in Lower Extremity Soft Tissue Sarcoma Patients After Limb Salvage

Limb Salvage

This study aims to: validate the Finnish version of the Musculoskeletal Tumor Society scale and the Toronto Extremity Salvage Score lower extremity sections and to assess the functional ability and health-related quality of life (HRQoL) of lower extremity sarcoma patients who have undergone limb salvage surgery.

Completed8 enrollment criteria

Transcutaneous Oxygen as a Predictor of Wound Healing Complications in Preoperatively Radiated Soft...

SarcomaSoft Tissue

Wound complications after sarcoma resection are frequent and potentially devastating problem. The burden of surgical wound complications in the lower extremity after preoperative external beam radiation therapy (EBRT) for soft tissue sarcoma is estimated at 43%. A noninvasive method of predicting complications would be extremely beneficial. The aim of this study is to evaluate the relationship between preoperative skin oxygenation and wound outcomes in a multi-center prospective analysis. This information could lead to a change in practice regarding surgical timing and adjunctive interventions to improve wound healing outcomes.

Completed10 enrollment criteria

Studying Genes in Tissue Samples From Younger and Adolescent Patients With Soft Tissue Sarcomas...

Childhood Alveolar Soft-part SarcomaChildhood Angiosarcoma13 more

This research trial studies genes in tissue samples from younger and adolescent patients with soft tissue sarcomas. Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors find better ways to treat cancer

Completed6 enrollment criteria

YONDELIS (Trabectedin) Single Patient Compassionate Use / Expanded Access

Soft Tissue Sarcoma

The YONDELIS (trabectedin) Single Patient Compassionate Use /Expanded Access program provides patients with advanced soft tissue sarcoma, who do not qualify for ongoing clinical trials with YONDELIS (trabectedin), access to this investigational treatment.

No longer available19 enrollment criteria

Chemotherapy-induced Symptoms in Sarcoma Patients and the Impact of Tumor Burden

Soft Tissue Sarcoma

Assessments (survey data) in this study are designed to sample the symptom burden of patients undergoing adjuvant and neoadjuvant chemotherapy in the hospital. There will be no change in the treatment plan for these patients.

Completed2 enrollment criteria
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