MK0249 for the Treatment of Cognitive Impairment in Patients With Schizophrenia (0249-016)
Paranoid SchizophreniaThe purpose of this study is to determine the safety and effectiveness of an investigational drug MK0249 for the treatment of the cognitive impairment in patients with schizophrenia.
Comparison of Intramuscular Olanzapine and Intramuscular Haloperidol in Patients With Schizophrenia...
SchizophreniaThe purpose of this study is to compare intramuscular Olanzapine and intramuscular Haloperidol in changing of agitation in patients with schizophrenia
Pilot Study of Atomoxetine To Enhance COgnition In Patients With Schizophrenia
SchizophreniaRelationships between altered prefrontal cortical dopamine, norepinephrine and some cognitive impairments of schizophrenia supports and approach for pharmacological remediation of cognitive symptoms through manipulations of prefrontal cortical dopamine and norepinephrine. Atomoxetine, a selective norepinephrine re-uptake inhibitor, produces a widespread increase in brain norepinephrine and a secondary and selective increase in prefrontal dopamine. Given this, we are evaluating atomoxetine's cognitive effects in a pilot placebo controlled trial in patients with schizophrenia. Moreover, an fMRI investigation was undertaken to assess the neural mechanisms underlying the cognitive effects of atomoxetine.
Effectiveness of Vitamin Supplementation in Treating People With Residual Symptoms of Schizophrenia...
SchizophreniaThis study will evaluate the effectiveness of folate and B12 supplementation in reducing negative symptoms in people with schizophrenia.
Enhancing Motivation To Quit Smoking In Smokers With Serious Mental Illness
SchizophreniaSchizoaffective DisorderThis project will assess the utility of a brief motivational intervention to engage smokers with schizophrenia in treatment for tobacco dependence treatment. It is hypothesized that a brief motivational intervention will be more effective in engaging smokers with schizophrenia to tobacco dependence treatment than an educational intervention. The educational intervention will increase the likelihood to reducing cigarette intake and/or attending tobacco dependence treatment by teaching subjects about the negative effects of smoking and the success of tobacco dependence treatment. The motivational intervention will increase the likelihood to reducing cigarette intake and/or attending tobacco dependence treatment by increasing subjects' motivation to change by presenting objective and personalized information regarding their smoking behaviors in a non-judgmental and supportive manner.
Motivational Interviewing to Improve Work Outcomes in Schizophrenia
Schizoaffective DisorderSchizophreniaMany persons with schizophrenia have difficulty getting and keeping a job. This study is designed to compare the benefits of four sessions of motivational interviewing or illness education in increasing employment rates accruing from participation in supported employment.
An Efficacy and Safety Study of Long-Term Risperidone Microspheres in Participants With Schizophrenia...
SchizophreniaSchizoaffective DisorderThe purpose of this study is to evaluate the long-term efficacy and safety of a long-acting injectable formulation of risperidone (an antipsychotic medication) and its influence on quality of life, in participants with schizophrenia (psychiatric disorder with symptoms of emotional instability, detachment from reality, often with delusions and hallucinations, and withdrawal into the self).
A Study of the Effectiveness and Safety of Long-acting Injectable Risperidone Versus Placebo in...
SchizophreniaPsychotic DisordersThe purpose of the study is to compare the effectiveness and safety of a long-acting injectable formulation of risperidone (an antipsychotic medication) versus placebo for the treatment of the symptoms of schizophrenia over a 12-week period.
Safety and Efficacy of Seroquel in First Episode Schizophrenia
SchizophreniaTo compare the safety, tolerability and efficacy of Seroquel and risperidone in first episode schizophrenia
A Study of Relapse Prevention and the Effectiveness of Long-acting Injectable Risperidone and Quetiapine...
SchizophreniaPsychotic DisordersThe purpose of this study is to investigate whether a long-acting injectable formulation of risperidone provides better effectiveness over 2 years, as measured by the time to relapse, compared with quetiapine tablets in a routine psychiatric care setting. Aripiprazole will be investigated in a descriptive manner.