The Effects of Aripiprazole on Patients With Metabolic Syndrome
SchizophreniaSchizoaffective Disorder2 moreThe primary goal of this study is to assess the effect of aripiprazole on patients who developed metabolic syndrome while taking other second generation antipsychotic medications.
A Comparative Study of New Medications for Psychosis in Adolescents
Psychotic DisordersSchizophrenia2 moreThe overall goal of this study is to determine the efficacy and tolerability of three atypical antipsychotic medications (risperidone, olanzapine, and quetiapine) in the treatment of adolescents with psychosis. It is hypothesized that the three medications will be equally effective in reducing the symptoms of psychosis.
A Study of Risperidone in Combination With Lorazepam Compared With Standard Therapy for Emergency...
SchizophreniaPsychotic Disorders1 moreThe purpose of the study is to show that risperidone (an antipsychotic medication) combined with lorazepam (an anti-anxiety medication) is more effective than conventional therapy administered by intramuscular injection for emergency treatment of patients with schizophrenia.
A Comparison of the Effectiveness and Safety of Injectable Risperidone With That of Risperidone...
SchizophreniaPsychotic DisordersThe primary purpose of the study is to show that treatment with an injectable formulation of risperidone is not less effective than and has a similar safety profile to risperidone tablets in patients with chronic schizophrenia.
A Trial Comparing Risperidone Long-Acting Injection With Oral Antipsychotic in the Treatment of...
SchizophreniaSchizoaffective Disorder2 moreThe purpose of this study is to evaluate the effectiveness, safety and tolerability of risperidone long-acting injection (LAI) versus oral antipsychotics in participants with recent onset psychosis (abnormal thinking and/or hallucinations).
An Open-label Study Evaluating the Maintenance of Clinical Effect in Adult Schizophrenia Patients...
SchizophreniaThe purpose of this study is to evaluate the maintenance of clinical effect of a rapidly-dissolving tablet form of risperidone (an antipsychotic medication) in adult schizophrenia patients switched from their previous equivalent dose of RISPERDAL® tablets
Quetiapine Fumarate (SEROQUEL) in the Treatment of Adolescent Patients With Schizophrenia and Bipolar...
SchizophreniaBipolar I DisorderThe purpose of this study is to demonstrate the efficacy and safety of quetiapine fumarate (SEROQUEL) in the treatment of adolescent patients with schizophrenia and bipolar I disorder.
Efficacy and Safety Study of Escitalopram Augmentation in Treatment Resistant Schizophrenia
SchizophreniaSchizoaffective DisorderA primary hypothesis to be explored here is that, given its pharmacodynamic profile and hypothesized mechanisms associated with schizophrenia, escitalopram will, in comparison to placebo, be effective when added to risperidone or olanzapine treated group in reducing the severity of resistant symptoms, particularly existing subsyndromal anxiety and depression.
A Study of the Effects of Risperidone and Olanzapine on Blood Glucose (Sugar) in Patients With Schizophrenia...
SchizophreniaDiabetes MellitusThe purpose of this study is to assess and compare how risperidone and olanzapine, two antipsychotic medications, affect the regulation of glucose (sugar) in the body.
The Effects of Nicotine Withdrawal on Reward Responsivity in Schizophrenia
SchizophreniaSchizoaffective DisorderIt has been suggested that patients with schizophrenia smoke in order to produce amelioration of dysfunctional dopaminergic pathways allowing them to experience pleasure and satisfaction and overcome anhedonia. No studies have assessed the effects of nicotine withdrawal on reward responsivity in patients with schizophrenia. The investigators believe that an understanding of this is crucial if improved treatments for nicotine dependence are to be developed for this patient population. If this group already has deficits in reward responsivity as a symptom of the disease then they may be particularly prone to the effects of nicotine withdrawal on reward systems. Smoking cessation may lead to a further decrease in their responsivity to pleasurable stimuli and worsening anhedonia. Treatments for smoking cessation may need to ameliorate any increased deficits if they are likely to be effective in patients with schizophrenia.