Seizure Treatment in Glioma
GliomaCurrently, treatment with a specific anti-epileptic drug mainly depends on the physicians' preference, as there are no studies supporting the use of one specific anticonvulsant in glioma patients. The overall aim of this randomized controlled trial is to directly compare the effectiveness of treatment with levetiracetam or valproic acid in glioma patients with a first seizure.
Acute Effects of Focused Ultrasound Modulation on EEG Behavior in Status Epilepticus Patients
SeizuresIn this study, the investigators propose Pulsed Low-Intensity Focused Ultrasound (PLIFU) stimulation of brain regions that modulate (thalamus) or generate focal motor seizures (primary motor cortex), with the goal of ameliorating seizure activity in subjects in non-convulsive or focal motor status epilepticus. The course of treatment will consist of an initial 10 minute PLIFU treatment session with an option for a 2nd session if necessary. The primary objective of this study is to determine whether PLIFU reduces or suppresses epileptic activity in patients with Non-Convulsive Status Epilepticus (NCSE)/Focal Motor Status Epilepticus (FMSE) that have not responded to standard of care.
A Study to Test the Safety and Tolerability of Staccato Alprazolam in Study Participants 12 Years...
Stereotypical Prolonged SeizuresThe purpose of the study is to evaluate the long-term safety and tolerability of Staccato alprazolam.
Cenobamate Open-Label Extension Study for YKP3089C025
Primary Generalized Tonic Clonic Seizures in the Setting of Idiopathic Generalized Epilepsy52 Week Open-Label Safety Study of Cenobamate for Subjects who Complete YKP3089C025 (core study)
Thermocoagulation in Drug Resistant Focal Epilepsy
EpilepsySeizures4 moreTherapeutic thermocoagulation will be carried out in patients with drug-resistant focal epilepsy in cases where an epileptogenic zone is found and proven according to stereo-electroencephalography (SEEG) data.
A Study to Test the Safety/ Efficacy of Brivaracetam (BRV) Used as Adjunctive Treatment in Subjects...
Partial Seizures With or Without Secondary GeneralizationEpilepsyThe purpose of the study is to evaluate the long-term safety and tolerability of Brivaracetam (BRV) in focal epilepsy subjects with partial seizures and to evaluate the maintenance of efficacy of BRV over time.
The Efficacy and Safety of Minocycline in the Treatment of Drug-resistant Epilepsy in NORSE Patients...
Epileptic Seizures Related to DrugsExploring the efficacy and safety of oral minocycline combined with antiepileptic drugs in the treatment of drug-resistant epilepsy in NORSE patients, obtaining preliminary research data, and providing evidence and data support for the next large-scale randomized controlled clinical study.
Extension Study to Evaluate the Safety and Tolerability of NBI-921352 When Used With Anti-seizure...
Focal Onset SeizureFocal Onset EpilepsyThis Phase 2, prospective, interventional, active extension study was designed to evaluate the long-term safety and tolerability of NBI-921352 as adjunctive therapy in adult participants with focal onset seizures who completed 11 weeks of treatment in randomized, double-blind, placebo-controlled Study NBI-921352-FOS2021. Eligible participants may enroll directly following the completion of the Week 11 study visit of Study NBI-921352-FOS2021 or after a gap following completion of that study.
An Open-label Extension Trial of CVL-865 as Adjunctive Therapy in the Treatment of Focal Onset Seizures...
SeizuresThe purpose of this study is to assess the long-term safety and tolerability of CVL-865 as adjunctive therapy in participants with focal onset seizures.
Acoustic Stimulation for Seizure Suppression
EpilepsyThe objective of this study is to test the feasibility and physiological effect of low-frequency (1 Hz) acoustic stimulation delivered during nocturnal NREM sleep in epilepsy patients. The long-term goal is to develop this protocol for daily, long-term use in a home setting, for nocturnal seizure and IED suppression