A Trial to Support Caregivers of Patients With Dementia in Italy: the UP-TECH Project
Alzheimer DiseaseThe UP-TECH project aims at developing an UPgrading quality of care for Alzheimer's disease patients through the integration of services and the use of new TECHnologies in order to also improving the quality of life of their family caregivers.
Effects of Sleep Deprivation on Cerebrospinal Fluid (CSF) Amyloid-beta (Aβ) Dynamics
Alzheimer DiseaseIntroduction: Alzheimer's disease (AD) is characterized by neurodegeneration of the brain in the form of neurofibrillary tangles and plaques containing the amyloid-beta protein (Abeta). Recent animal studies have shown that extended wakefulness is associated with increased production of these Abeta proteins and that sleep leads to a marked fall in their production. Aim: The investigators aim to distinguish a similar effect of sleep disturbance on cerebrospinal fluid (CSF) Abeta levels in humans, which may point out sleep disturbance as an important factor in AD development. Methods: a study in 26 healthy male volunteers, measuring CSF Abeta levels during a sleep deprivation night and before and after a control night with unrestricted sleep. Expected results: The investigators expect sleep deprivation to lead to an increase in CSF Abeta levels, as compared to the levels in the control night.
Multiple Dose Study of TRx0037
Alzheimer's DiseaseThe purpose of this study is to evaluate the safety, tolerability and pharmacokinetics of TRx0037 after multiple doses in elderly volunteers.
A Two-part Multiple Dose Study to Assess the Safety and Effects of AZD3293 in Healthy Elderly and...
Healthy Elderly VolunteersMild-to-moderate Alzheimer's Disease PatientsThis is a two-part multiple dose study in healthy male and female (of non-child bearing potential) elderly volunteers, and in Alzheimer's disease patients, to assess the safety, effects on the body, and blood, CSF, and urine drug levels of AZD3293. AZD3293 is being developed for the treatment of Alzheimer's Disease
Effectiveness of Care Management in Alzheimer Patients
Alzheimer Disease or Associated DisorderMild to Moderately Severe DementiaContext: The French Alzheimer plan 2008-2012 includes the implementation of "disease managers" or social workers, from the onset of the disease, for every patient with a diagnosis of Alzheimer disease or associated disorder. However, previous trials evaluating the efficacy of a systematic intervention for each case from the onset of the disease, including non complex cases, have shown little evidence. Objective: To evaluate the efficacy of a social worker to prevent behavioural problem for patient with a new diagnosis of Alzheimer disease or associated disorder. Design and setting: Multicentric cluster randomized control trial. Patients from several memory consultations and specialists (neurologist, psychiatrist or geriatrician) in France are included. Intervention: In addition to usual care, patients in the intervention group have systematic home visits from a social worker and regular follow-ups by phone over a one-year period. This social worker informs the patient and caregiver, evaluates the needs, gives advices to prevent complications and is a link between the patient and the memory consultation or the specialist. Patient in the control group have absolutely no intervention and are followed-up as usually. In order to not modify the usual care, they have no information on their participation in this trial before the one-year evaluation. Main outcome measure: NeuroPsychiatric Inventory (NPI) administrated at one year, which evaluates frequency, severity and repercussion of several behavioural problems. Secondary outcomes included disability, cognition, depression, health, quality of life, institutionalization, and resource use.
A Biomarker Study of Solanezumab in Patients With and Without Alzheimer's
Alzheimer's DiseaseThe purpose of this trial is to compare the average change in the amount of amyloid beta species in blood after an infusion of solanezumab.
A Study To Evaluate The Abuse Potential Of Single Oral Doses Of Dimebon (Latrepirdine) In Healthy...
Alzheimer's DiseaseHuntington's DiseaseDimebon will not exhibit abuse potential when compared to placebo or a positive control (alprazolam).
Effect on the Electrocardiographic QT Interval Corrected for Heart Rate (QTc) in Healthy Subjects...
Alzheimer DiseaseThe purpose of this study is to determine the effect of BMS-708163 on the QTc interval (QT interval corrected for heart rate).
A Study Evaluating The Absorption Of Dimebon Into The Body From A Dimebon Solution Applied To The...
Alzheimer's DiseaseHuntington's DiseaseTo estimate the absorption, safety, and tolerability of a dimebon transdermal solution relative to the dimebon immediate release oral formulation.
Relative Bioavailability Study of Four Experimental Formulations for Alzheimer's Disease
Alzheimer's DiseaseHealthyThe purpose of this study is to assess the bioavailability of four experimental formulations relative to the current reference formulation used in the Phase 2 study.