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Active clinical trials for "Shock, Septic"

Results 71-80 of 645

Safety and Feasibility of Metformin for Sepsis Induced AKI

SepsisSeptic Shock2 more

Acute kidney injury (AKI) is an independent risk factor for death that affects 10-15% of hospitalized patients and more than 50% of patients admitted to the intensive care unit. Sepsis is the most frequent cause of AKI, affecting 48 million people worldwide every year, and accounting for approximately 11 million of annual global deaths. Despite these figures, there are no known therapies to prevent or reverse septic AKI; hence this study aims to establish the safety and feasibility of the implementation of metformin in the treatment of AKI in patients with sepsis. This study is the first critical step to inform the design of a future, full-scale efficacy randomized clinical trial.

Not yet recruiting17 enrollment criteria

Cardiovascular Effects of Norepinephrine

Septic Shock

Previous studies of our team reported the improvement of myocardial contractility both on hemodynamic parameters (by transpulmonary thermodilution) and morphological (by transthoracic echocardiography: TTE), during the early phase of septic shock (during the first 4 hours management of septic shock). However, one can wonder about the effect of NAD on myocardial cardiac ouput and contractility beyond the early phase of septic shock, more precisely beyond the first 24 hours. Indeed, while it continues to act on the "stressed" blood volume and the diastolic left ventricular perfusion by increasing the diastolic arterial pressure (DAP), it has been reported in old studies that beyond the early phase, the sensitivity of the β1-adrenergic receptors is altered due to the phenomenon of internalization of these receptors, leading to a reduction of the myocardial response to catecholamines. The investigators can then wonder whether norepinephrine still exerts a positive effect on myocardial contractility via the increase in DAP, despite an alteration of the β1-adrenergic pathway. To answer this question, the investigators proposed to evaluate the effects of norepinephrine by TTE on cardiac contractility after the initial phase.

Recruiting6 enrollment criteria

Effectiveness of Anisodamine Hydrobromide Combined With Heparin for the Treatment of Critically...

Septic Shock

The study aimed to investigate the effectiveness of anisodamine hydrobromide combined with heparin in the treatment of septic shock, in the hope that the therapy will provide alternatives to the treatment of septic shock.

Not yet recruiting8 enrollment criteria

Human Albumin Treatment in Adult Septic Shock. A Study Evaluating Immune Response and Organ Failure....

Septic Shock

The goal of this phase 2, multicenter, randomized, controlled study is to evaluate the effect of albumin treatment on B cell and other immune cell gene exptression in adults with septic shock.

Not yet recruiting24 enrollment criteria

Mannheim Register of Sepsis and Septic Shock

Severe SepsisSeptic Shock

The study aims to investigate clinically and prognostically relevant parameters in patients with sepsis and septic shock within a monocentric observational clinical register.

Recruiting2 enrollment criteria

Therapeutic Plasma Exchange in Septic Shock: A Pilot Study

Septic Shock

At the Health Sciences Centre and St. Boniface Hospital in Winnipeg, Manitoba, the investigators propose to conduct a two-center randomized trial comparing therapeutic plasma exchange to standard of care in patients diagnosed with septic shock.

Not yet recruiting15 enrollment criteria

Effects of Fluid Therapy on Peripheral TIssse Perfusion During Sepsis/Septic Shock

Septic ShockSepsis

Compare the effect of volume expansion by saline versus albumin on the correction of peripheral tissue hypoperfusion by measuring Index skin recoloration time (CRT) at H0 and H1

Recruiting14 enrollment criteria

Evaluation of Parameters Collected From Routine Data for the Diagnosis of Sepsis and Septic Shock...

SepsisSeptic Shock

Retrospective observational study to develop a Machine Learning Algorithm to evaluate parameters collected from routine data for the diagnosis of sepsis and septic shock and their influence on time to diagnosis and patient outcome.

Recruiting3 enrollment criteria

Lactate Kinetics in Septic Shock

SepsisSeptic Shock

Lactate kinetics will be studied in hospitalized septic patients using a bolus injection of stable isotopically labeled lactate.

Recruiting7 enrollment criteria

Iron Metabolism Disorders in Patients With Sepsis or Septic Shock.

Iron-deficiencyIron Deficiency Anemia3 more

Anemia is a common health problem. Depending on a geographical region, anemia affects even 50% of population. Among patients admitted to the intensive care unit (ICU) anemia may affect as much as 66% of patients. Moreover, many patients develop anemia during the ICU stay. In general population the most common cause of anemia is iron deficiency (ID). The investigators lack information on the incidence of ID and anemia of inflammation (AI) with absolute ID (mixed type of anemia: AI + IDA) or functional ID (AI) in patients with sepsis or septic shock hospitalised in the ICU. Therefore, the aim of the study is to improve diagnosis of iron deficiency (ID) and anemia of inflammation (AI) with absolute ID (AI + IDA) or functional ID (AI) in patients with sepsis or septic shock. ID have negative effects on the body and is associated with impaired production of proteins responsible for transport of oxygen in the blood (hemoglobin) and oxygen storage (myoglobin), and impaired immune function. Development of anemia is associated with well documented complications: organ hypoxia, myocardial infarction, stroke, infection. Replenishment of iron at this early stage may potentially prevent IDA. It is advantageous to replenish iron stores in order to avoid these complications, especially in patients with sepsis or septic shock. In IDA red blood cell transfusion is not recommended as it leads to other numerous complications. Therefore the patients presenting with laboratory results suggesting ID will receive divided doses od parenteral iron. Monitoring of iron replenishment will be based on a new laboratory parameter- reticulocyte hemoglobin equivalent.

Recruiting5 enrollment criteria
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