Use of Cross-linked Donor Corneas as Carriers for the Boston Keratoprosthesis
Chemical InjuriesUnspecified Complication of Corneal Transplant7 moreThe purpose of the pilot study is to test the efficacy and safety of riboflavin/Ultraviolet A (UVA) cross-linked human donor corneas as carriers for the Boston Keratoprosthesis (Boston KPro) in patients with higher risk for corneal melting (keratolysis).
Efficacy of 0.05% Cyclosporin Eye Drop in Stevens Johnson Syndrome Patient With Chronic Dry Eye...
Stevens-Johnson SyndromeThe purpose of this study is to evaluate the efficacy of 0.05% cyclosporin ophthalmic emulsion (Restasis) in patients with Stevens-Johnson syndrome that have dry eyes by subjective symptoms and signs.
G-CSF in the Treatment of Toxic Epidermal Necrolysis
Stevens - Johnson SyndromeNeupoNET aims to evaluate interest of G-CSF in the treatment of Toxic Epidermal necrolysis. This is a prospective randomized controlled trial. Patients will be allocated in a treatment group (receiving an injection of 5 microg/kg/d of G-CSF during 5 consecutive days) or in a placebo group. Patients will be randomized at admission and will be followed until 3 months after discharge.
Salivary Gland Transplantation in the Treatment of Dry Eye in Patients With Stevens-Johnson Syndrome....
SymblepharonDry Eye2 moreThe purpose of this study is to evaluate salivary gland and labial mucous membrane transplantation in patients with severe symblepharon and dry eye secondary to Stevens-Johnson Syndrome (SJS).
Autologous ex Vivo Conjunctival Epithelial Cell Expansion for Ocular Surface Transplantation
PterygiumOcular Surface Disease2 moreTo evaluate the use of cultivated conjunctival epithelial equivalents for the treatment of ocular diseases
Study of a Potential New Treatment for Patients With Toxic Epidermal Necrolysis (TEN)
Toxic Epidermal NecrolysisTo determine whether treatment of patients who have toxic epidermal necrolysis with a drug called remicaide increases the number of patients who are alive 30 days laters.
Topical Clobetasol for the Treatment of Toxic Epidermal Necrolysis
Toxic Epidermal NecrolysisThe primary objectives of this study are to investigate the efficacy and safety of topical steroid ointment (clobetasol 0.05%) for the treatment of the cutaneous manifestations of toxic epidermal necrolysis (TEN).
Safety and Performance Study of the ARGOS-IO System in Patients Undergoing Boston Keratoprosthesis...
Graft vs Host DiseaseCongenital Aniridia3 moreThe ARGOS-IO pressure sensor is intended to be implanted in the human eye in combination with Boston Keratoprosthesis (BKPro) surgery and to remain in place indefinitely. It is intended to be used together with the hand-held Mesograph reading device to telemetrically measure the intraocular pressure (IOP) of patients with a BKPro. The purpose of this study is to evaluate the safety and performance of the ARGOS-IO system in patients undergoing concomitant implantation of a BKPro and an ARGOS-IO sensor over the 12 month period beginning at implantation.
Infliximab to Improve Retention of the Boston Keratoprosthesis in Patients After Stevens Johnson...
Stevens-Johnson SyndromeCorneal BlindnessThe proposed study is intended to test the idea, based upon current knowledge of the biology and physiology of corneal ulceration in SJS/TENS patients who receive a keratoprosthesis, and on the known effects of infliximab on matrix metalloproteinases, that infliximab therapy for such patients may reduce the likelihood of corneal ulceration, and hence extend the period of prosthesis retention and vision recovery.
Evaluating the Effect of Isotretinoin in Regulatory T-cell Function in Adverse Cutaneous Drug Eruptions...
Toxic Epidermal NecrolysisThe purpose of this study is to determine whether isotretinoin is helpful in treating patients with an adverse cutaneous drug eruption known as toxic epidermal necrolysis (TEN).