Rivastigmine For Methamphetamine Dependent Individuals
Substance-Related DisordersMethamphetamine abuse has been steadily increasing over the past decade. Rivastigmine is a medication that may be helpful in treating methamphetamine dependence. The purpose of this study is to evaluate the effectiveness of rivastigmine in treating methamphetamine dependent individuals.
The Efficacy of Methadyl Acetate (LAAM) and Contingency Management Procedures for Treating Dual...
Behavior TherapyCocaine6 moreAlthough LAAM, a derivative of methadone, has been successfully used as an alternative to methadone maintenance in opioid addicts, its effect on concurrent opioid and cocaine abuse has not been ascertained. Thus, this study proposes to examine the clinical efficacy of low- and high-dose LAAM maintenance on opioid and cocaine use in opioid-dependent cocaine abusers. In addition, since contingency management procedures have demonstrated some success in decreasing cocaine use in cocaine-abusing individuals, this study also proposes to examine the clinical efficacy of the presence or absence of contingency management procedures targeting illicit drug use.
Family Intervention for Mental Illness and Substance Abuse
SchizophreniaBipolar Disorder1 moreThis study will evaluate a family intervention program for individuals with bipolar disorder, schizophrenia, or schizoaffective disorder and co-occurring substance use disorders.
Buprenorphine and Naloxone for the Treatment of Opiate Dependence - 1
Heroin DependenceSubstance-Related DisordersThe purpose of this study is the use of buprenorphine/naloxone in treatment of opioid dependence.
Motivational Interviewing to Improve Treatment Engagement and Outcome in Subjects Seeking Treatment...
Substance-Related DisordersThe purpose of this study is to assess Motivational Interviewing (MI) to improve treatment engagement and outcome in subjects seeking treatment for substance abuse.
Reserpine for the Treatment of Cocaine Dependence - 1
Cocaine-Related DisordersSubstance-Related DisordersThe purpose of this study is to assess the efficacy and safety of reserpine for the treatment of cocaine dependence.
Atomoxetine to Treat Adolescents With Coexisting Alcohol and Other Substance Use Disorder and ADHD...
Substance Use DisordersAttention Deficit Hyperactivity DisorderThe purpose of this study is to compare the effectiveness and safety of atomoxetine in the treatment of adolescents with coexisting alcohol or substance use disorders and Attention Deficit Hyperactivity Disorder (ADHD).
Integrating Clinical Practice Guidelines for Smoking Cessation Into Mental Health Care for Veterans...
Mental HealthStress Disorders3 moreThe primary study objective is to conduct a prospective, randomized controlled clinical trial that compares the effectiveness of two approaches for delivering smoking cessation treatment for veterans with posttraumatic stress disorder (PTSD). An approach where smoking cessation treatment is integrated into mental health care for PTSD and delivered by mental health providers (experimental condition) will be compared to specialized smoking cessation clinic referral (VA's usual standard of care). Secondary study objectives are to (a) compare the cost outcomes and cost-effectiveness of IC versus USC, (b) identify treatment process variables that explain (mediate) observed differences in smoking abstinence rates for the two study conditions, and (c) determine whether cessation from smoking is associated with worsening of symptoms of PTSD and/or depression.
Brain Changes in Stimulant Dependent Subjects - 8
Substance-Related DisordersThe purpose of this study is to identify the neurophysiologic indicators of cocaine or methamphetamine use and withdrawal, to examine the relationship between subjects' reports of depression, craving, and stimulant use, and neurophysiologic measures, and to identify neurophysiologic measures which can be used to identify new treatments for stimulant dependence.
Carbamazepine Treatment of Cocaine Dependence - 1
Cocaine-Related DisordersSubstance-Related DisordersThe purpose of this study is to compare the efficacy of carbamazepine in treatment of cocaine-dependence in patients with affective disorders.