
Safety and Efficacy of the Novel Selective Nicotinic Receptor Partial Agonist, CHANTIX (Varenicline)...
SmokingAcute Coronary SyndromeAssess the role of a nicotine antagonist in helping patients presenting to hospital with acute coronary syndrome to stop smoking.

Polycystic Ovary Syndrome (PCOS): Effect Of Letrozole and Berberine
Polycystic Ovary SyndromePolycystic ovary syndrome (PCOS) is a heterogeneous disorder affecting almost4%-7% of the female population of reproductive age. Its heterogeneity is characterized by a wide spectrum of features, including ovulatory dysfunction and infertility, hyperandrogenism, hyperinsulinemia, insulin resistance (IR), and progression to type 2 diabetes.Since the Ming Dynasty in China,PCOS has been defined as "phlegm and wetness"infertility in traditional Chinese medicine ,namely "metabolic infertility".Chinese herbs have been used to treat PCOS for thousands of years with good effects.Berberine has also been used for diabetic patients in traditional Chinese medicine for hundreds of years. Recent studies have reported its effects on hyperglycemia and dyslipidemia.The purpose of this study is to determine whether Letrozole combined with berberine are effective in the treatment of infertile PCOS patients.

Protandim and the Metabolic Syndrome
Metabolic SyndromeProtandim will decrease markers of oxidative stress/inflammation in subjects with metabolic syndrome and proteomics will identify protein profiles that correlate with markers or/changes in oxidative stress.

Use of Decitabine in Myelodysplastic Syndrome (MDS) Following Azacitidine (AZA) Failure
Acute Myeloid LeukemiaChronic Myelomonocytic Leukemia1 moreThe purpose of this study is to assess the response rate at 6 months in Myelodysplastic Syndrome (MDS) patients, Chronic Myelomonocytic Leukaemia (CMML-2) patients, and Acute Myeloid Leukaemia (AML) patients with up to 30% bone marrow blasts, treated with low-dose decitabine who have previously failed therapy with 5-azacitidine.

The Effect of Weight Loss on Anti-Müllerian Hormone Levels in Women With Polycystic Ovary Syndrome...
ObesityPolycystic Ovaries SyndromeThe first aim of the investigators study, was to investigate the combined effect of diet,physical exercise and orlistat, for 24 weeks, on serum Anti-Müllerian Hormone (AMH) levels in obese women with polycystic ovary syndrome (PCOS) and in obese controls. The other aim of the investigators study, was to examine the effect of hypocaloric diet,physical exercise plus sibutramine on serum AMH levels, body composition, hormonal and metabolic parameters in overweight and obese patients with polycystic ovary syndrome (PCOS).

RadIal Versus Femoral InvEstigation in ST Elevation Acute Coronary Syndrome
Coronary Artery DiseaseAcute Coronary Syndrome1 moreProspective, randomized, multi-center trial comparing the safety and efficacy in the prevention of net adverse clinical outcomes (NACE) of transfemoral vs. transradial approach for the treatment of patients with ST-elevation acute coronary syndrome (STEACS) undergoing primary angioplasty

Botulinum Toxin Injections for Thoracic Outlet Syndrome
Thoracic Outlet SyndromeBotulinum toxin type A injected into the anterior and middle scalene muscles will reduce the irritation on the neurovascular structures at the interscalene triangle in subjects with TOS. This will lead to reductions in pain and paresthesias, and improvements in function when compared with injection of placebo.

Treatment of Hepatorenal Syndrome With Terlipressin Infusion Adjusted to Hemodynamic Response
CirrhosisHepatorenal Syndrome Type IObserve the effect of terlipressin on renal function in patients with SHR type I adjusting the dose based on hemodynamic response.

Irritable Bowel Syndrome and Low FODMAP Diet
Irritable Bowel SyndromeThe patients having a syndrome SII would be more intolerant in the fructose than the healthy subjects and would benefit from a fructose diet but also from the fructans which contain some fructose. The intolerance in the fructose is diagnosed thanks to a respiratory test after absorption of fructose. However, the eviction of the fructose is sometimes recommended to the patients without having realized beforehand the test of intolerance.

Percutaneous Tibial Nerve Stimulation in the Treatment of Anterior Resection Syndrome After Rectal...
Rectal CancerLow Anterior Resection SyndromeThe study aims to evaluate the efficacy of percutaneous tibial nerve stimulation (PTNS) associated with conservative therapy (arm A) for the treatment of low anterior resection syndrome (LARS) compared with only conservative therapy (arm B). The secondary aims are the evaluation of the following parameters: Effect of PTNS on manometric parameters Effect of PTNS on quality of life Effect of PTNS on the severity of fecal incontinence and / or obstructed defecation Safety of PTNS