Group Cognitive Behavioral Therapy (CBT) Intervention for Women With Mild to Moderate Depression...
DepressionAnxietyThe purpose of this study is to develop a structured CBT group intervention for women with depression of mild or moderate severity and to pilot a randomized controlled trial to compare this intervention with usual care in socially deprived areas in Bristol, incorporating qualitative methods to assess acceptability.
Switching to Duloxetine in Patients With Depression
Depressive DisorderMajorThe purpose of this study is to help answer the following research question: Whether switching to duloxetine improves depressed mood when current treatment did not work well for patients with depression.
Duloxetine Treatment of Major Depression and Chronic Low Back Pain For Older Adults
Major Depressive DisorderBack Pain1 moreThe following primary hypotheses will be tested: During Step 1: Major Depressive Disorder (MDD) or Chronic Low Back Pain (CLBP) in < 40% of the initial 60 subjects treated with duloxetine (DUL) + Clinical Management(CM) during the first 8 weeks will respond (response is defined as a Montgomery Asberg Depression Rating Scale (MADRS) score </=9 and at least a 30% improvement in back pain as measured with the 20-point numeric rating scale. During Step 2: More DUL+Problem Solving Therapy for Depression and Pain (PST-DP) than DUL+CM treated subjects will achieve response during the second 8 weeks, defined as a MADRS score </=9 and at least a 30% improvement in back pain as measured with the 2-point numeric rating scale. Improvement in depression scores will be correlated with improvement in CLBP scores. The exploratory hypotheses to be tested are that: During Step 2: Compared to subjects treated with DUL+CM, subjects treated with DUL+PST-DP will have improved outcomes in: 1) disability, 2) sleep, 2) functioning/quality of life, 3) caregiver burden/depression, and 5) analgesic use.
An Investigation of Sleep Architecture in Ziprasidone-Treated Bipolar Depression
DepressionBipolarThis study uses polysomnographs(PSG) to investigate sleep patterns in patients with bipolar depression. This is a double-blind, placebo-controlled, study of ziprasidone that is added to patients current medications. The objective is to relate changes in slow wave and rapid eye movement sleep to changes in mood and overall illness severity. Participants will be randomly assigned to add either placebo or ziprasidone to their current treatment regimen. Participants make 3 to 4 study visits, over a 1 month period, at which they will be asked about their history, mood and sleep quality. Participants will also have three in-home overnight polysomnographs.
Does Concurrent Hydrocortisone With Venlafaxine XR Speed Antidepressant Response?
Depressive DisorderMajorThe primary purpose of this study is to examine whether IV hydrocortisone can speed up the time required for Venlafaxine XR to work.
Depression: The Search for Treatment-Relevant Phenotypes-Pilot Study
Major DepressionWe are doing this pilot study to learn more about four aspects of treating depression: The features of a depressed person's mood and anxiety and how these features affect a person's capacity to get better and stay better. If depressed people with certain features of mood and anxiety respond better to therapy, medication or a combination of therapy and medication. Whether or not a person's personality traits affect how they respond to treatment. The gene involved in processing antidepressant medication
Magnetic Resonance Imaging Study of Geriatric Depression
Major Depressive DisorderThe purpose of this study was to use Magnetic Resonance Images to further our understanding of predictors and markers of treatment response and non-response in geriatric depression. We hypothesized that concentrations of high energy metabolites would be lower in depressed elderly compared to non-depressed.
A Study to Determine the Efficacy and Safety of 2 Doses of Org 34517 as Adjunctive Therapy in Subjects...
DepressionDepressive Disorders1 moreThe primary purpose of this study is to determine whether subjects with psychotic major depression benefit from adjunctive treatment with Org 34517. Two doses of Org 34517 will be compared to placebo in this international multicenter study. The duration of this trial is 6 weeks.
Acamprosate Added to Escitalopram and Behavioral Treatment for Comorbid Depression and Alcoholism...
Major Depressive DisorderAlcohol Abuse1 moreThis is a study about treatment for people who suffer from both major depression and alcohol abuse or dependence. The study will examine whether the addition of acamprosate to escitalopram and behavioral interventions will improve outcomes for this population.
Safety & Efficacy Study of Quetiapine Fumarate (SEROQUEL®) vs. Placebo and Active Control in Major...
Major Depressive DisorderThis study is to evaluate that (SEROQUEL®) quetiapine sustained-release is efficacious and safe in the treatment of patients with MDD.