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Active clinical trials for "Urinary Incontinence, Urge"

Results 131-140 of 156

Treatment of Urge Urinary Incontinence in Women After Failure of Cesa or Vasa

Surgical Treatment of Urge Incontinence

Urge urinary incontinence can be a disorder caused by destroyed pelvic structures. We repaired the uteri-sacral ligaments (USL) by cesa or vasa. The study evaluates if solifenacin can lead to continence after surgery or if also the pubo-urethral ligaments (PUL) need to be repaired.

Unknown status9 enrollment criteria

EFFECTIVENESS OF THE NEUROADAPTATIVE FOR URGE INCONTINENCE

Urge Incontinence

In this clinical trials the sponsor want to assess a self-controlled-energo-neuroadaptative-regulation in patient with urge incontinence

Unknown status15 enrollment criteria

Reduction of Bladder Injection Pain With Belladonna Opiate Suppository

Overactive BladderUrinary Urge Incontinence3 more

The purpose of this study is to test whether using belladonna & opiate suppositories (B&Os) can improve patient discomfort during Onabotulinumtoxin A (BoNT) injection into the bladder for treatment of overactive bladder, neurogenic detrusor overactivity, or interstitial cystitis.

Completed9 enrollment criteria

Surgical vs. Medical Treatment of Urge Urinary Incontinence in Women

Urge Urinary Incontinence

The purpose of this study is to determine if pelvic surgery can improve urge urinary incontinence in women more than standard medical treatment.

Unknown status8 enrollment criteria

Do Patient Anxiety Levels Decrease Urodynamic Test Reproducibility?

AnxietyOveractive Bladder5 more

This study will look at how pre-test anxiety levels affect the reproducibility of symptoms during routine urodynamic testing in women. Urodynamics is a test that assesses the function of the lower urinary tract, including the bladder.

Completed4 enrollment criteria

Central Nervous System Changes Following BotulinumtoxinA Injection in the Bladder

Multiple SclerosisLower Urinary Tract Symptoms4 more

The purpose of this prospective research study is to evaluate higher neural changes following intradetrusor injection of Botulinum toxin-A (BTX-A) in patients with Multiple Sclerosis (MS). Concurrent Urodynamic and Functional Magnetic Resonance (fMRI) data will be recorded pre- and post- intravesical injection of BTX-A in patients with Multiple Sclerosis (MS) and neurogenic detrusor activity (NDO). Other objectives are to evaluate the role of urinary biomarkers such as brain-derived neurotropic factor (BDNF) and nerve growth factor (NGF) associated with bladder overactivity and, to determine whether the common validated urgency questionnaires correlate with fMRI findings and urinary biomarker concentration pre- and post- BTX-A injection in patients with MS and NDO.

Completed8 enrollment criteria

Higher Neural Changes Following Anticholinergic, Beta 3 Agonist, or Placebo in Patients With Overactive...

Overactive BladderDementia3 more

Women presenting with overactive bladder symptoms will be randomized to one of 3 arms (anticholinergic, beta-3 agonist, placebo). They will undergo baseline cognitive testing, functional MRI of the brain. Cognitive testing and functional MRI will be repeated after taking their double blinded intervention for 30 days.

Unknown status10 enrollment criteria

Time to be Ready to Void: a New Tool to Assess the Time Needed to Perform Micturition in Multiple...

Gait DisordersNeurologic3 more

The aim of the study is to create a specific test to assess the global time required to go to the toilet and to perform micturition, at the moment the patient decides to urinate in multiple sclerosis population, and to assess its reliability.

Completed5 enrollment criteria

Urgent-SQ in Treatment of Overactive Bladder Syndrome: 9-yr Follow up

Overactive BladderUrinary Frequency or Urgency Adverse Event2 more

Long term open label study on safety and durability of the Urgent-SQ tibial implant device for refractory overactive bladder syndrome (OAB).

Completed2 enrollment criteria

SMAD2, SMAD3 AND TGF-β GENE EXPRESSION IN URGE URINARY INCONTINENCE

SMAD2SMAD33 more

Urge urinary incontinence (UUI) is a common health problem. Changes in collagen metabolism in pelvic support organs, such as uterosacral ligaments (USLs), might be responsible for the complex pathophysiology of UUI. The TGF-β pathway is involved in collagen synthesis and degradation. The Transforming Growth Family- β (TGF-β) superfamily has essential intracellular signaling components, such as newly identified SMAD family members. We evaluated the changes in the levels of TGF-β and SMAD gene and protein expression in the USL of patients with concomitant pelvic organ prolapse (POP) and UUI.

Completed12 enrollment criteria
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