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Active clinical trials for "Ventricular Premature Complexes"

Results 31-40 of 67

Beta-blocker vs. Ic Antiarrhythmic Drug for PVC

Premature Ventricular Complex

The standard medical therapy of idiopathic premature ventricular complex consists of beta blocker and Ic antiarrhythmic agent. However, the difference in the efficacy of two drugs has not been well investigated. This prospective randomized study aimed to compare the efficacy of beta-blocker and Ic antiarrhythmic agent in the treatment of symptomatic patients with idiopathic premature ventricular complex.

Unknown status2 enrollment criteria

TAES for FPVCs: a Pragmatic, Randomized Controlled Trial

Premature Ventricular Contraction

This prospective, pragmatic, randomized controlled trial aims to evaluate the efficacy and safety of transcutaneous acupoint electrical stimulation (TAES) for patients with frequent premature ventricular contractions (FPVCs). Ninety participants will be randomized to TAES group and sham-TAES group with the ratio of 1:1. They will receive TAES plus usual care or sham-TAES plus usual care for 6 weeks, and then be followed up for 12 weeks after the treatment. The primary outcome was the proportion of participants with a 50% decrease of the 24 hour (24h) premature ventricular contractions (PVCs) after 6-week treatment. Secondary outcomes include the proportion of participants with a 75% decrease of the 24h-PVCs; the decrease from baseline of 24h-PVCs, total 24h-heartbeat, and the frequency of supraventricular arrhythmia; the score change from baseline in PVCs-related symptoms; the score change from baseline in SAS and SDS. Subgroup analyses will be performed in age, gender, and the severity of PVCs. Safety assessment will be documented during the whole trial.

Unknown status12 enrollment criteria

Remote Magnetic Versus Manual Navigation-guided Ablation for Non-outflow Tract Premature Ventricular...

Premature Ventricular Contraction

This prospective, randomized, controlled trial is designed to compare the safety and efficacy of remote magnetic navigation-guided ablation for ventricular premature complexes arising from non-outflow tracts with manual control navigation.

Unknown status10 enrollment criteria

Study to Reduce Symptoms of Premature Beats With Ranolazine

Premature Ventricular Beats

Investigate whether ranolazine, a novel anti-anginal agent with antiarrhythmic properties, has a role in the management of symptomatic ventricular premature beats.

Unknown status16 enrollment criteria

Shensong Yangxin Capsule in the Treatment of Heart Failure Complicated With Ventricular Premature...

Heart FailureVentricular Premature Complex

The purpose of this study is to assess the effects of Chinese medicine Shensong Yangxin capsule for the chronic cardiac dysfunction complicated with ventricular premature beats.

Unknown status10 enrollment criteria

Comparision of PVC Ablation Techniques

Premature Ventricular Contraction

Several reports have shown the utility of PVC ablation with cryo catheters. The aim of this study is to compare the outcomes and safety of Cryo vs. RF for PVCs.

Unknown status7 enrollment criteria

Effects of Carvedilol on Suppressing the Premature Ventricular Complex/Ventricular Tachycardia From...

Ventricular Premature ComplexesOutflow Tract1 more

Carvedilol is known to be effective in reducing ventricular arrhythmias and mortality in patients with heart failure. It is suggested that one of the mechanisms is its ability to block store overload-induced Calcium release which activates spontaneous calcium release by Ryanodine receptors. Ventricular outflow tract tachyarrhythmia is known to be associated with calcium overload due to activation of Ryanodine receptors. The aim of this study is to evaluate the efficacy of Carvedilol on premature ventricular complex(PVC)/ventricular tachycardia(VT) originating from outflow tract.

Unknown status8 enrollment criteria

Prospective Assessment of Premature Ventricular Contractions Suppression in Cardiomyopathy(PAPS)...

Ventricular Premature BeatsContractions2 more

Premature ventricular contractions (PVCs) coexist in patients with heart failure (HF) and LV dysfunction. Frequent PVCs have shown to induce a reversible cardiomyopathy (PVC-CM). This clinical pilot study will enroll 36 patients with frequent PVCs (burden >10%) and CM (LVEF <45%) and randomize them to either: 1) RFA or 2) AADs. Prior to treatment, patients will undergo a baseline cardiac MR if clinically indicated followed by 3-month observation period (optimal HF medical therapy). Changes in LV function/scar, PVC burden/arrhythmias and clinical/functional status (QOL, HF symptoms and admissions, NYHA class) and adverse events will be assessed throughout the observation period and compare with PVC suppression strategies (RFA or AAD). Similar comparison will be made between RFA and AAD treatment groups during a 12-month follow up using a Prospective Randomized Open, Blinded End-point (PROBE) study design. The treatment regimens will be compared in an intention-to-treat analysis. In addition, a total of 20,000 consecutive ambulatory ECG Holter monitors from all participating centers will be screened to identify all patients with probable diagnosis of PVC-CM. This pilot study is intended to estimate the prevalence of this clinical entity and pave the way for a large full scale randomized trial to identify best treatment strategy for patients with PVC-CM. Treating and reversing this underestimated PVC-CM may improve patient's health and subsequently decrease HF healthcare spending.

Unknown status22 enrollment criteria

Premature Ventricular Contractions (PVCs) and Blood Pressure Control

Ventricular Premature ComplexesBlood Pressure

The purpose of this study is to determine if reduction in premature ventricular contraction (PVC) burden results in a decrease in blood pressure, sympathetic outflow, plasma catecholamines and an improvement in baroreflex gain. Flecainide will be used for PVC suppression in a randomized, double-blinded, crossover fashion.

Terminated16 enrollment criteria

Reversal of Cardiomyopathy by Suppression of Frequent Premature Ventricular Complexes

Heart DiseasesCardiac Arrhythmias3 more

Frequent monomorphic premature ventricular complexes (PVCs) may cause a cardiomyopathy (CMP) that is reversible by suppression of the ectopic focus. This study investigates whether PVC suppression therapy can improve cardiac function and clinical condition of patients with idiopathic or ischemic CMP and frequent monomorphic PVCs. For this purpose, patients will be randomized to either one of two treatment strategies: 1) conventional heart failure therapy plus PVC suppression therapy, consisting of RFCA as primary treatment and Amiodarone as secondary treatment in case of unsuccessful RFCA, or 2) conventional heart failure therapy without PVC suppression therapy.

Unknown status20 enrollment criteria
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