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Active clinical trials for "Heart Septal Defects, Ventricular"

Results 11-20 of 49

Angiotensin Converting Enzyme Inhibition in Children With Mitral Regurgitation

Heart DefectsCongenital4 more

This study will evaluate the efficacy and safety of angiotensin converting enzyme inhibition (ACE-I) therapy for the treatment of mitral regurgitation (MR).

Terminated9 enrollment criteria

Cera™ VSD Occluder Post Market Clinical Follow-up

Ventricular Septal Defect

The objective of this post-market registry is to assess the safety and performance of the Lifetech Cera™ VSD occluder in a real-world and on-label fashion.

Not yet recruiting2 enrollment criteria

A Phase I Study of Dexmedetomidine Bolus and Infusion in Corrective Infant Cardiac Surgery: Safety...

Transposition of the Great ArteriesTetralogy of Fallot1 more

The purpose of this Phase I study is to determine the safety of a drug called dexmedetomidine (DEX) as part of a balanced general anesthetic and sedative strategy for neonates and infants undergoing corrective cardiac surgery that requires the use of cardiopulmonary bypass for congenital cardiac problems. This study will also design and validate a dosing schema for the use of DEX as described above.

Completed13 enrollment criteria

Transcatheter Versus Surgical Closure of Ventricular Septal Defect: A Comparative Study

Heart DefectsCongenital

The aim of this study is to compare Safety, efiicacy and clinical effects of surgical versus transcatheter closure of ventricular septal defect (VSD ). The outcome of interest is success rate, residual shunts, effect on tricuspid and aortic valves, need for blood transfusion, length of hospital and intensive care unit ( ICU ) stay, complications especially complete heart block, affection of kidney functions due to the procedure length caused by Cardiopulmonary bypass in case of surgical group or by the dye used in the group of transcatheter closure.

Completed24 enrollment criteria

A Randomized Controlled Trial:Treatments on Infundibular Ventricular Septal Defect

Heart Septal DefectsVentricular7 more

The purpose of this study is to investigate the security and validity of transesophageal echocardiography(TEE)-guided perventricular device closure(TPDC) through minithoracotomy in treatment of infundibular ventricular septal defect(IVSD) with asymmetric occluder.

Completed2 enrollment criteria

Hybrid Closure of Congenital Heart Disease

Pediatric Ventricular Septal Defects

Ventricular septal defect (VSD) is one of the most common pediatric congenital malformations. In recent years, in view of the rapid rise of transthoracic minimally invasive hybrid closure for pediatric VSD in the clinical practice, precision assessment of perioperative its effectiveness and safety has already become an important issue that must be solved. On the basis of echocardiography, integrating with characteristics associated critical care, the investigators focus on precision assessment of perioperative effectiveness and safety of transthoracic hybrid closure for pediatric VSD, compared with conventional surgical sternotomy repair with cardiopulmonary bypass (CPB).

Completed7 enrollment criteria

Transcatheter Closure Versus Surgery of Perimembranous Ventricular Septal Defects

Ventricular Septal Defects

The purpose of this study is to investigate effectiveness and safety of transcatheter closure of perimembranous ventricular septal defects.

Completed2 enrollment criteria

Measures to Lower the Stress Response in Pediatric Cardiac Surgery

Tetralogy of Fallot (TOF)Ventricular Septal Defects (VSD)1 more

Cardiac surgery induces a measurable stress response in patients which leads to increased morbidity and mortality post-operatively. Through clinical observation, anesthesiologists have determined that varying the combinations of anesthesia drugs used during surgery and just after reduces the stress response, and by extension, morbidity and mortality. However, only a few studies have explored this phenomenon scientifically.

Completed4 enrollment criteria

Hypertonic Saline Dextran in Pediatric Cardiac Surgery

Heart DefectsCongenital4 more

The purpose of this study is to determine whether infusion of hypertonic saline dextran attenuates the inflammatory response and the water overload, during and after major cardiac surgery in small children.

Completed4 enrollment criteria

Infant Heart Surgery: Central Nervous System Sequelae of Circulatory Arrest

Cardiovascular DiseasesCerebral Anoxia7 more

To compare the influence of two surgical anesthetic techniques, hypothermia with circulatory arrest or hypothermia with low-flow bypass perfusion, on neurologic functioning in infants undergoing heart surgery.

Completed1 enrollment criteria
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