Angiotensin Converting Enzyme Inhibition in Children With Mitral Regurgitation
Heart DefectsCongenital4 moreThis study will evaluate the efficacy and safety of angiotensin converting enzyme inhibition (ACE-I) therapy for the treatment of mitral regurgitation (MR).
Cera™ VSD Occluder Post Market Clinical Follow-up
Ventricular Septal DefectThe objective of this post-market registry is to assess the safety and performance of the Lifetech Cera™ VSD occluder in a real-world and on-label fashion.
A Phase I Study of Dexmedetomidine Bolus and Infusion in Corrective Infant Cardiac Surgery: Safety...
Transposition of the Great ArteriesTetralogy of Fallot1 moreThe purpose of this Phase I study is to determine the safety of a drug called dexmedetomidine (DEX) as part of a balanced general anesthetic and sedative strategy for neonates and infants undergoing corrective cardiac surgery that requires the use of cardiopulmonary bypass for congenital cardiac problems. This study will also design and validate a dosing schema for the use of DEX as described above.
Transcatheter Versus Surgical Closure of Ventricular Septal Defect: A Comparative Study
Heart DefectsCongenitalThe aim of this study is to compare Safety, efiicacy and clinical effects of surgical versus transcatheter closure of ventricular septal defect (VSD ). The outcome of interest is success rate, residual shunts, effect on tricuspid and aortic valves, need for blood transfusion, length of hospital and intensive care unit ( ICU ) stay, complications especially complete heart block, affection of kidney functions due to the procedure length caused by Cardiopulmonary bypass in case of surgical group or by the dye used in the group of transcatheter closure.
A Randomized Controlled Trial:Treatments on Infundibular Ventricular Septal Defect
Heart Septal DefectsVentricular7 moreThe purpose of this study is to investigate the security and validity of transesophageal echocardiography(TEE)-guided perventricular device closure(TPDC) through minithoracotomy in treatment of infundibular ventricular septal defect(IVSD) with asymmetric occluder.
Hybrid Closure of Congenital Heart Disease
Pediatric Ventricular Septal DefectsVentricular septal defect (VSD) is one of the most common pediatric congenital malformations. In recent years, in view of the rapid rise of transthoracic minimally invasive hybrid closure for pediatric VSD in the clinical practice, precision assessment of perioperative its effectiveness and safety has already become an important issue that must be solved. On the basis of echocardiography, integrating with characteristics associated critical care, the investigators focus on precision assessment of perioperative effectiveness and safety of transthoracic hybrid closure for pediatric VSD, compared with conventional surgical sternotomy repair with cardiopulmonary bypass (CPB).
Transcatheter Closure Versus Surgery of Perimembranous Ventricular Septal Defects
Ventricular Septal DefectsThe purpose of this study is to investigate effectiveness and safety of transcatheter closure of perimembranous ventricular septal defects.
Measures to Lower the Stress Response in Pediatric Cardiac Surgery
Tetralogy of Fallot (TOF)Ventricular Septal Defects (VSD)1 moreCardiac surgery induces a measurable stress response in patients which leads to increased morbidity and mortality post-operatively. Through clinical observation, anesthesiologists have determined that varying the combinations of anesthesia drugs used during surgery and just after reduces the stress response, and by extension, morbidity and mortality. However, only a few studies have explored this phenomenon scientifically.
Hypertonic Saline Dextran in Pediatric Cardiac Surgery
Heart DefectsCongenital4 moreThe purpose of this study is to determine whether infusion of hypertonic saline dextran attenuates the inflammatory response and the water overload, during and after major cardiac surgery in small children.
Infant Heart Surgery: Central Nervous System Sequelae of Circulatory Arrest
Cardiovascular DiseasesCerebral Anoxia7 moreTo compare the influence of two surgical anesthetic techniques, hypothermia with circulatory arrest or hypothermia with low-flow bypass perfusion, on neurologic functioning in infants undergoing heart surgery.