Trial of Talabostat and Gemcitabine in Patients With Stage IV Adenocarcinoma of the Pancreas
Pancreatic Cancer, Neoplasm Metastasis, Adenocarcinoma
About this trial
This is an interventional treatment trial for Pancreatic Cancer focused on measuring pancreatic cancer, cancer of the pancreas, adenocarcinoma of the pancreas, pancreatic neoplasms, Metastatic pancreatic cancer (Stage IV), Stage IV Adenocarcinoma of the Pancreas
Eligibility Criteria
Inclusion Criteria: Men or women age ≥18 years Histologically confirmed metastatic (stage IV) adenocarcinoma of the pancreas Measurable disease defined per RECIST Karnofsky Performance Status ≥50 Expected survival ≥12 weeks Provide written informed consent Exclusion Criteria: CNS metastases Prior treatment with other chemotherapy for pancreatic cancer unless used as a radiosensitizer Radiation therapy to >25% of the bone marrow Clinically significant laboratory abnormalities Any malignancy within the 5 years immediately prior to the first dose of study medication with the exception of basal cell or non-metastatic squamous cell carcinoma of the skin, and carcinoma in-situ of the cervix The need for chronic (i.e., >7 days) oral or intravenous corticosteroid therapy with >10mg/day prednisone equivalents Any comorbidity or condition which, in the opinion of the investigator, may interfere with the assessments and procedures of this protocol Patients who are within 28 days of radiation therapy, biologic therapy, immunotherapy, or other investigational medication. All side effects of prior treatment must have resolved at study entry. Pregnancy or lactation
Sites / Locations
- Northwest Alabama Cancer Center, PC
- Northwest Alabama Cancer Center, PC
- Oncology Associates, PC
- Palm Beach Institute of Hematology and Oncology
- Cancer Center of Florida
- Hematology Oncology Associates of Central Brevard
- Gulfcoast Oncology Associates
- Yagnesh V. Oza, MD
- Indiana Oncology Hematology Consultants
- Cancer Care Center, Inc.
- Medical Oncology LLC
- Huron Medical Center
- Billings Clinic
- Monmouth Medical Center
- New York Oncology Hematology/Albany Regional Cancer Center
- Hematology-Oncology Associates of Rockland
- Dayton Oncology and Hematology
- Lawrence M. Stallings, MD
- Trilogy Cancer Center
- Providence Portland Medical Center
- Oregon Clinic, The
- Cancer Center of the Carolinas
- Mary Crowley Medical Research Center
- Texas Oncology, PA, Presbyterian
- Baylor College of Medicine
- Elkins Pancreas Center
- Saint Luke's Episcopal Hospital
- Cancer Care Northwest