Efficacy of Cognitive Rehabilitation Using Virtual Reality and Computer-based Cognitive Stimulation on Cognitive Impairment Associated to Movement Disorders (CogMusT)
Parkinson Disease, Huntington Disease
About this trial
This is an interventional treatment trial for Parkinson Disease focused on measuring Cognitive impairment, Cognitive rehabilitation, Virtual reality, Music therapy, Computer-based cognitive rehabilitation
Eligibility Criteria
Inclusion Criteria: Patient capable of understanding, signing and dating the written informed consent at baseline visit prior to randomization. Patient diagnosed with Parkinson's disease (Movement Disorder Society PD Criteria) or Huntington's disease. Patient with Hoehn and Yahr stage I-III for PD, and Shoulson and Fahn stage I-II for HD. Patient with a score on the Parkinson's Disease Cognitive Rating Scale (PD-CRS) >83, who present subjective memory complaints will be included in "group I: subjective memory complaints". Patient with a score on the Parkinson's Disease Cognitive Rating Scale (PD-CRS) between 64 and 83, both inclusive, will be included in "group II: mild cognitive impairment". Patient diagnosed with Parkinson's disease with stable dopaminergic treatment in the last 4 weeks. Patient capable and willing to comply with study visits as detailed in the protocol. Exclusion Criteria: Illiterate patients. Patients with severe vision or hearing impairment. History of deep brain stimulation surgery. Patients diagnosed with severe dementia (possible or probable) associated with Parkinson's disease, according to the Clinical Diagnostic Criteria for Dementia Associated with PD with a score of >2 on the CRD or with Huntington's disease. Patients with active psychosis in the form of incapacitating delusional ideation. Patients who were under experimental treatment in the 2 months prior to the selection period. Patients with any of the following conditions: Life expectancy of less than 6 months. Any severe or uncontrolled medical condition. Patients with a history of poor treatment compliance or drug/alcohol abuse that may interfere with the patient's ability to comply with the study protocol or give informed consent. Pregnancy or breastfeeding. Contraindications for MRI*. Except for patients with Parkinson's disease (PD), since MRI is optional for these patients. Therefore, if there are contraindications for MRI, they can still participate without undergoing MRI.
Sites / Locations
- Hospital de la Santa Creu i Sant Pau
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Active Comparator
Experimental
Active Comparator
Immersive Virtual Reality (Parkinson's disease)
Computer-based cognitive rehabilitation (Parkinson's disease)
Computer-based cognitive rehabilitation (Huntington's disease)
Music-therapy (Huntington's disease)