The Effect of Chronic Remote Ischaemic Preconditioning on Blood Pressure in Older Adults (RIPCo)
Hypertension, Vascular Diseases

About this trial
This is an interventional treatment trial for Hypertension focused on measuring Remote Ischaemic Preconditioning, Non-pharmacological, Remote Ischaemic Conditioning, Randomised Controlled Trial
Eligibility Criteria
Inclusion Criteria: Participant is aged >65y and <85y. Participant is willing and able to give informed consent for participation in the study. Participant is physically able to perform RIPC. Exclusion Criteria: A BMI <18 or >35 kg/m2 Active cardiovascular, cerebrovascular or respiratory disease: e.g. uncontrolled hypertension (BP > 160/100), active angina, heart failure (class III/IV), arrhythmia, right to left cardiac shunt, recent cardiac event, COPD, pulmonary hypertension or recent (6 mo) stroke. If history of hypertension, no recent alteration to antihypertensive medication (3 months). A history of, or current neurological or musculoskeletal conditions (e.g. epilepsy) Having taken part in a research study in the last 3 months involving invasive procedures or an inconvenience allowance
Sites / Locations
- School of Medicine, Royal Derby Hospital Site, University of NottinghamRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Sham Comparator
Remote Ischaemic Preconditioning
Sham remote ischaemic preconditioning
RIPC is induced by 4 cycles of 5 minutes of healthy upper limb ischaemia followed by 5 minutes reperfusion. Ischaemia is induced by inflation of a blood pressure cuff to 20mmHg above systolic blood pressure. RIPC is conducted 3 times weekly for 6-weeks.
Sham RIPC is induced by 4 cycles of 5 minutes of healthy upper limb ischaemia followed by 5 minutes reperfusion. Ischaemia is induced by inflation of a blood pressure cuff to 20mmHg. RIPC is conducted 3 times weekly for 6-weeks