Cell-free Autologous Regenerative Endodontics Treatment for Teeth With Periapical Lesions (CARETT) (CARETT)
Periapical Diseases, Pulp Necroses
About this trial
This is an interventional treatment trial for Periapical Diseases focused on measuring Regenerative Endodontics, Permanent Dentition, Pulp Necroses, Periapical Diseases, Root Canal Filling Material
Eligibility Criteria
Inclusion Criteria:
- Male or female (18-60y) systemically healthy or chronic disease controlled
- Uniradicular or multiradicular permanent mature teeth
- Teeth with diagnosis of pulp necrosis (negative response to thermal-cold pulp test) and sings or symptoms (clinical-radiographic) of periapical lesion.
- Root anatomy with curvatures ≤ 30°
- Feasibility of adhesive tooth restoration (direct or indirect)
- Voluntary participation under informed consent
Exclusion Criteria:
- Pregnant or lactating woman
- Signs of moderate or severe periodontal disease
- Teeth with signs of radicular fracture (vertical or horizontal), signs of root resorption (endo-exo)
- teeth with impossibility of good prognosis of coronary rehabilitation by direct or indirect adhesive technique
- Teeth that to treat can not to be correctly isolate with rubber dam
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Regenerative Endodontic Treatment
Conventional root canal treatment
This treatment consists of obturated the root canal preparations under an biological-based protocol using autologous biological elements and bioactive materials that allows restore the connective pulp-like tissue within the canals.
This treatment consist on obturated the root canal preparations under the conventional protocol with an inert biomaterials like guttapercha and endodontics cements to seal the root canals.