Effectiveness of a Low Carbohydrate Diet Versus a High Carbohydrate Diet in Promoting Weight Loss and Improved Health
Obesity, Hypertension
About this trial
This is an interventional treatment trial for Obesity focused on measuring Diet, Carbohydrates, Weight Loss
Eligibility Criteria
Inclusion Criteria: Body mass index (BMI) of 27 to 50 Fasting glucose less than 126 mg/dl Total fasting cholesterol less than 260 mg/dl Total fasting triglycerides less than 400 mg/dl Permission of primary care provider to participate in the study Normal liver and kidney function Willing to modify diet and other health behaviors Willing to use an acceptable method of contraception for the duration of the study Exclusion Criteria: Any medical condition that may make weight loss medically inadvisable Weigh more than 400 lbs History of kidney failure Current use of more than 3 blood pressure medications Change in blood pressure medications within 3 months prior to study entry Diagnosis of cardiovascular disease within 6 months prior to study entry Cancer diagnosis within 2 years of study entry. Participants with basal cell skin cancer are not excluded. History of psychiatric hospitalization within 2 years prior to study entry Consumption of more than three alcoholic drinks a day Type I or II diabetes Current use of hypolipidemics, antipsychotics, hypoglycemics, glucocorticoids, or thyroid medication Plan to move during study Current participation in another clinical trial Pregnancy or breastfeeding
Sites / Locations
- Kaiser Permanente Center for Health Research
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Atkins Diet
DASH Diet
Participants randomized to this arm will consume a low carbohydrate diet as described by Dr. Robert Atkins in his book: Dr. Atkins' New Diet Revolution New York: Avon Books, 2002.
Participants randomized to this arm will consume the Dietary Approaches to Stop Hypertension (DASH) diet as described here: http://www.nhlbi.nih.gov/health/public/heart/hbp/dash/new_dash.pdf