Fat Gain and Cardiovascular Disease Mechanisms
Hypertension, Sleep Apnea Syndromes, Obesity
About this trial
This is an interventional prevention trial for Hypertension
Eligibility Criteria
Inclusion Criteria: We will enroll up to 180 subject in order to fulfill screening requirements and have complete studies in 120 total (60 with and 60 without family history hypertension). Gender: Male and female. Ages: 18 to 40 (inclusive). Exclusion Criteria: Body-mass index > 33 kg/m2 Tobacco smoking or chewing Shift worker Any diseases Any prescription medications (except, oral contraceptives are permitted)
Sites / Locations
- Mayo Clinic
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
1
2
Subjects who are randomized to overfeed will visit with the General Clinical Research Center dieticians as often as necessary to gain 2 kg of fat (about 4 kg overall) over a period of 8 weeks.
Subjects who are randomized to non-overfeeding will continue with their normal diet and activity levels for a period of 8 weeks.