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Active clinical trials for "Opioid-Related Disorders"

Results 141-150 of 1134

Integrating Addiction Treatment and HIV Services Into Primary Care Clinics in Ukraine

HivOpioid-use Disorder

A cluster-randomized RCT to: To compare both primary (composite quality health indicator (QHI) scores) and secondary (individual HIV/methadone maintenance treatment (MMT)/TB/primary care QHI scores, quality of life, and stigma) outcomes in 1,350 people who inject drugs (PWID) receiving MMT from 15 regions (clusters) and 45 clinical settings using a stratified, phase-in, cluster-controlled design over 24 months. After stratifying PWIDs based on their current receipt of MMT, they will be randomized to receive MMT in specialty addiction clinics (N=450) or in an ECHO-IC/QI-enhanced primary care clinic with (N=450) or without (N=450) pay for performance (P4P) incentives; Using a multi-level implementation science framework, to examine the contribution of client, clinician and organizational factors that contribute to the comprehensive composite (primary outcome) and individual (secondary) QHI scores; and To conduct a cost-effectiveness analysis (CEA) of integrating HIV/MMT into PC sites, with or without P4P, compared to a control group of specialized MMT sites.

Recruiting4 enrollment criteria

SMART Trial for Buprenorphine-Naloxone Medication Assisted Treatment Adherence

Opioid-use Disorder

The purpose of this study is to compare the effectiveness of two different interventions for medication-assisted treatment (MAT) adherence: Contingency Management (CM) and Brief Motivational Interviewing + Substance Free Activities + Mindfulness (BSM).

Enrolling by invitation5 enrollment criteria

Impact of Bridge™ Device to Treat Opioid Withdrawal Symptoms

Opioid Use Disorder

The purpose of this prospective study is to investigate the efficacy of the Bridge™ device in reducing the symptoms of opioid withdrawal in a blind comparison to a sham device.

Enrolling by invitation16 enrollment criteria

Reduced Opioid Prescription After Laparoscopic Hysterectomy

PainPostoperative3 more

Given the nationwide epidemic of opioid use and abuse (in part due to over prescription), this study aims at addressing the need for opioid prescription after laparoscopic hysterectomy.

Recruiting7 enrollment criteria

Effectiveness of a CBT-based mHealth Intervention Targeting MOUD Retention, Adherence, and Opioid...

Opioid-use Disorder

The focus of this study is to examine the effectiveness of imFREE relative to mHealth ED in facilitating treatment retention and adherence and reducing opioid use among adults with OUD initiating BUP treatment. There are two specific aims: (1) to test the effectiveness of imFREE, delivered in conjunction with medical management with buprenorphine (imFREE + MM), relative to mHealth ED + MM, in facilitating buprenorphine treatment retention and adherence in a population of individuals with OUD initiating MM (N=200). (2) To evaluate the cost-effectiveness of imFREE.

Enrolling by invitation10 enrollment criteria

iSTART: A Campus & Community Initiative for Services in Tec-health

Substance UseBinge Drinking4 more

The iSTART intervention is a 30-day substance prevention web-app whereby students complete five weekly interactive modules using a smart device or computer. Each module is approximately 15 minutes long, and focuses on a select substance: (i) alcohol, (ii) marijuana, (iii) nicotine, (iv) prescription drugs, and (v) illicit drugs. The modules are based on key theoretical constructs, behavior change strategies, and practical module components: attitudes (knowledge), perceived susceptibility (risk perceptions), subjective norms (normative re-education), and self-efficacy (refusal skills). This intervention will be evaluated via a time series design using a sample of 600 students randomly assigned to either the intervention, comparison, or control condition at a public institution in southern California.

Recruiting5 enrollment criteria

PRescribing INterventions for Chronic Pain Via the Electronic Health Record Study - Current Opioid-User...

Opioid-use DisorderOpioid Use1 more

The objective of this research is to assess the effects of electronic health record (EHR)-based decision support tools on primary care provider (PCP) decision-making around pain treatment and opioid prescribing. The decision support tools are informed by principles of "behavioral economics," whereby clinicians are "nudged," though never forced, towards guideline-concordant care.

Recruiting2 enrollment criteria

Optimizing Evidence-based HIV Prevention Targeting People Who Inject Drugs on PrEP

HivOpioid Use Disorder

The investigators will conduct an optimization trial among N=256 PWID newly started on medication for opioid use disorder and Pre-Exposure Prophylaxis (PrEP) to assess the performance of four intervention components (Attention, Executive Functioning, Memory, and Information Processing) aimed at enhancing the ability of PWID on MOUD to process and utilize HIV prevention content, leading to improvements in HIV prevention information, motivation, behavioral skills, and behaviors (IMB).

Recruiting13 enrollment criteria

Collaboration Leading to Addiction Treatment and Recovery From Other Stresses

Opioid-use DisorderAddiction2 more

Collaboration Leading to Addiction Treatment and Recovery from Other Stresses (CLARO) is a five-year project that tests whether delivering care using a collaborative model helps patients with both opioid use disorders and mental health disorders.

Enrolling by invitation8 enrollment criteria

Randomized Controlled Trial: A Digital Intervention to Prevent the Initiation of Opioid Misuse in...

Opioid Misuse

The primary hypothesis of this study is that at 3 months, there will be a higher proportion of intervention participants vs. control participants who report greater risk of harm from misuse of prescription opioids AND heroin/fentanyl.

Recruiting7 enrollment criteria
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