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Active clinical trials for "Bacterial Infections"

Results 191-200 of 589

GSK1322322 Versus Linezolid in the Treatment of Acute Bacterial Skin and Skin Structure Infection...

Skin InfectionsBacterial

This study will determine the safety, tolerability and efficacy of GSK1322322 verses Linezolid in subjects with Acute Bacterial Skin and Skin Structure Infection (ABSSSI).

Completed32 enrollment criteria

Study Comparing the Safety and Efficacy of Two Doses of BC-3781 vs Vancomycin in Patients With Acute...

Bacterial InfectionsInfection

This is a Phase II, multi-center, randomized, double-blind study comparing the safety and efficacy of two doses of BC-3781 versus vancomycin in patients with acute bacterial skin and skin structure infection.

Completed3 enrollment criteria

Single Dose Escalation First Time in Human PK Study

InfectionsBacterial

This is a first time in human (FTIH) study of single escalating doses of investigational study drug to investigate safety, tolerability, and pharmacokinetics in healthy subjects

Completed21 enrollment criteria

A Safety and Efficacy Study of Doripenem in Participants With Nosocomial Pneumonia, Complicated...

InfectionCross Infection5 more

The purpose of this study is to assess the safety and efficacy of doripenem in participants with nosocomial pneumonia (inflammation of the lungs in which the lungs become heavy; pneumonia occurring at least 48 hours after hospital admission), complicated intra-abdominal (in belly) infections and complicated urinary tract infections (bladder infections).

Completed11 enrollment criteria

Relative Bioavailability Study in Healthy Subjects

InfectionsBacterial

Part 1 of this study will assess the relative bioavailability of GSK1322322 administered as one of three investigational tablets compared to powder in a bottle formulation. Pharmacokinetics of these three tablets will be evaluated and the investigation tablet with the optimal PK profile will be progressed to Part 2. In Part 2 the investigational tablet selected from Part 1 will be coadministered with food alone, an H2 blocker alone, or an H2 blocker given in combination with ascorbic acid to evaluate the effect on GSK1322322 pharmacokinetics. Plasma GSK1322322 PK profile, safety, and tolerability will be assessed from each dose group.

Completed22 enrollment criteria

Comparative Study of Ceftaroline vs. Vancomycin Plus Aztreonam in Adult Subjects With Complicated...

Bacterial Infections

The purpose of this study is to determine whether ceftaroline is effective and safe in the treatment of complicated skin infections in adults.

Completed3 enrollment criteria

Steroids for Corneal Ulcers Trial

Corneal UlcerEye Infections1 more

The purpose of this study is to determine whether adding topical steroids improves the outcomes of bacterial corneal ulcers, especially visual acuity.

Completed30 enrollment criteria

Ocular Pharmacokinetics After a Single Drop Instillation of T1225 0.5, 1, 1.5% in 91 Healthy Volunteers...

Eye InfectionsBacterial

To evaluate azithromycin tear concentrations after instillation of one drop of one of the three T1225 concentrations (0.5%, 1% and 1.5%) and to evaluate the ocular safety.

Completed13 enrollment criteria

Oral Antibiotic Treatment at Home Instead of Intravenous Treatment in Hospital for Resistant Gram...

Gram-positive Bacterial InfectionsStaphylococcal Infections

The main purpose of this study is to find out whether changing the hospital policy to allow switch from glycopeptide antibiotics (given by intravenous drip), to an equally effective oral antibiotic (linezolid) will enable patients who are otherwise well enough to be discharged from hospital sooner. The secondary objectives are To identify those patients who could potentially be discharged on an oral agent from those being treated with a glycopeptide, thus helping target this approach most effectively To evaluate the cost involved and compare this with the costs that would have taken place if use of an oral agent and discharge had not occurred.

Completed9 enrollment criteria

Effect of Chlorhexidine Cleansing on Skin Flora of Newborns in Nepal

Bacterial Infection

The purpose of this study is to compare the reductions in skin flora of newborns after a single cleansing of the body with three concentrations of chlorhexidine (0.25%, 0.5%, 1.0%) and to examine the safety of skin cleansing in neonates in Nepal.

Completed7 enrollment criteria
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