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Active clinical trials for "Bacterial Infections"

Results 251-260 of 589

Study Evaluating Tigecycline in Selected Serious Infections Caused by Vancomycin-Resistant Enterococcus...

Gram-Positive Bacterial InfectionsStaphylococcus Infections2 more

To evaluate the safety and efficacy of tigecycline in the treatment of selected serious infections caused by VRE. The primary efficacy endpoint will be the clinical response for all subjects.

Completed6 enrollment criteria

A Study to Compare Different Drugs Used to Prevent Serious Bacterial Infections in HIV-Positive...

Bacterial InfectionsPneumonia2 more

This study compares 2 different treatments administered to try to prevent serious bacterial infections (such as pneumonia) in HIV-positive children. A combination of drugs (azithromycin plus atovaquone) will be compared to sulfamethoxazole-trimethoprim (SMX/TMP) alone. This study also evaluates the long-term safety and tolerance of these different drugs. SMX/TMP is a commonly prescribed drug for the prevention of bacterial infections. However, the combination of azithromycin and atovaquone may be safer and more effective than SMX/TMP. This study compares the 2 treatments.

Completed9 enrollment criteria

Aerosolized Versus Intravenous Colistin-based Antimicrobial Regimens in Hospitalized COVID-19 Patients...

Secondary Bacterial Infection in COVID-19 Patients

Secondary bacterial pathogen infection has been demonstrated to aggravate COVID-19 clinical outcomes. Bacterial infections acquired during a hospital stay are likely resistant to several antimicrobial medicines, making COVID-19 patient management difficult. As a result, it is believed that aerosolized colistin might be a viable choice for treating secondary bacterial infections caused by gram-negative resistant strains in individuals who also have COVID-19 infection.

Completed3 enrollment criteria

Ecological Effect of Arginine Dentifrice on Oral Microbiota

Dental CariesOral Bacterial Infection1 more

caries-free (CF) individuals caries-active (CA) individuals (DMFT ≥ 6) will be recruited. Subjects will be instructed to brush their teeth twice daily for 3 min using Colgate® Sensitive Pro-Relief® toothpaste (containing 8% arginine and 1450 ppm NaF) for 2 weeks. Supra- and subgingival plaque, saliva, and in situ plaque samples will be collected before and after the treatment for laboratory analyses.

Completed2 enrollment criteria

Pharmacokinetics of Retapamulin in Pediatric Subjects With Uncomplicated Skin Infections.

Skin InfectionsBacterial

A study to evaluate the pharmacokinetics of Retapamulin Ointment, 1%, in pediatric subjects (2-24 months) with secondarily-infected traumatic lesions, secondarily-infected dermatoses, or impetigo (bullous and non-bullous).

Completed24 enrollment criteria

Study Comparing Tigecycline to Imipenem/Cilastatin in Complicated Intra-Abdominal Infections in...

Gram-Positive Bacterial InfectionsCross Infection

Purpose: To provide a mechanism for the emergency use of tigecycline in the appropriate clinical situations.

Completed6 enrollment criteria

Prediction of Multidrug-resistant Bacterial Infection in Patients With Cirrhosis

Drug ResistanceMultiple2 more

The aim of this study is to identify predictive factors of infections caused by multidrug-resistant organisms in patients with cirrhosis and to develop and validate (internally and externally) a predictive model that might be useful to use in clinical settings to stratify the risk and lead clinical decision-making strategies.

Active10 enrollment criteria

MeMed BV® Test Evaluation in Adult Emergency Department Patients

Respiratory InfectionRespiratory Infections in Old Age2 more

The goal of this observational study is to compare the results of a serum biomarker called the MeMed BV®, which is approved to help differentiate between bacterial and viral respiratory infections, to clinical diagnoses of adult emergency department patients presenting with recent fever and signs or symptoms of a respiratory infection. Active participation is completed during the emergency department visit and includes drawing blood, obtaining a sputum sample, and answering survey questions.

Active16 enrollment criteria

Temocillin Pharmacokinetic in Hemodialysis

Gram-Negative Bacterial InfectionsRenal Failure Chronic Requiring Hemodialysis

The current study aimed to explore the pharmacokinetics of temocillin in patients treated with haemodialysis and to demonstrated whether or not the pharmacodynamics target of a time above a MIC of 16 mg/L of more than 40 and 60 % of the dosing interval could be obtained with a dosing schedule of 1 gram/24 hours, 2 gram/48 hours and 3 gram/72 hours, all of these doses given after haemodialysis sessions only.

Completed6 enrollment criteria

Bioavailability Of Flucloxacillin Capsules (250 mg and 500 mg)

InfectionsBacterial

Primary objective:To study the absolute bioavailability, distribution and elimination parameters of flucloxacillin from two oral formulations of flucloxacillin in healthy male and/or female subjects.

Completed41 enrollment criteria
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