A Trial to Assess Brexpiprazole Versus Placebo for the Treatment of Acute Manic Episodes Associated...
Bipolar I DisorderManic EpisodeTo demonstrate the efficacy of brexpiprazole for the acute treatment of manic episodes, with or without mixed features, in participants with a diagnosis of bipolar I disorder.
Inositol and Omega-3 Fatty Acids in Pediatric Mania
Pediatric Bipolar Spectrum DisordersThe purpose of this study is to a) evaluate the efficacy of omega-3 fatty acids versus inositol in the treatment of pediatric bipolar disorder, b) evaluate the efficacy of omega-3 fatty acid plus inositol in the treatment of pediatric bipolar disorder, and c) assess the side effect profile of omega-3 fatty acids plus inositol. This study will be a 12-week trial with children ages 5-12 years old with bipolar spectrum disorders.
Study Evaluating Cariprazine (RGH-188) in the Treatment of Patients With Acute Mania
Bipolar DisorderThis is a study designed to evaluate the efficacy, safety, and tolerability of RGH-188 monotherapy in the treatment of acute mania. This study will be 5 weeks in duration; 3 weeks double-blind treatment and 2-weeks safety follow-up. All patients meeting the eligibility criteria will be randomized to one of two treatment groups: RGH-188 or placebo
Safety and Efficacy of Cariprazine for Mania
Bipolar DisorderManiaThe objective of this study is to evaluate the efficacy, safety, and tolerability of cariprazine monotherapy versus placebo for the treatment of acute manic or mixed episodes associated with bipolar I disorder.
Bipolar Intervention Study: Cognitive Interpersonal Therapy
ManiaHypomania1 moreThere is a need to develop a better understanding of the early phase of bipolar disorder, and to develop and evaluate effective psychosocial interventions that assist people in this phase. The purpose of this study is to determine whether or not it is feasible to conduct a larger study of the effectiveness of cognitive interpersonal therapy (a psychological therapy) with individuals who have experienced their first or second treated episode of mania or hypomania (symptoms common in early development of bipolar disorders).
Efficacy and Safety of Olanzapine in the Extended Treatment for Manic or Mixed Episode of Bipolar...
Manic or Mixed Episode Associated With Bipolar I DisorderThe efficacy and safety of the extended treatment to patients with most recent episode manic or mixed who completed previous double blind study (F1D-JE-BMAC [Study BMAC]) will be examined.
A Study of the Effectiveness and Safety of Risperidone Versus Placebo as add-on Therapy to Mood...
Bipolar DisorderManic DisorderThe purpose of the study is to evaluate the effectiveness and safety of risperidone (an antipsychotic medication) versus placebo as add-on therapy to mood stabilizers, in the treatment of manic episodes associated with bipolar disorder.
An Open-label Extension Study to Evaluate the Safety and Tolerability of Licarbazepine in the Treatment...
Bipolar I DisorderThis extension study is designed to investigate the long-term safety and tolerability of licarbazepine 750-2000 mg/day over 52 weeks in patients who completed the 3-week double-blind study CLIC477D2301.
Trial of Citicoline Therapy in Patients With Mania or Hypomania and Cocaine Abuse/Dependence
ManiaHypomania2 moreThe purpose of this research is to determine if a citicoline supplement is associated with a reduction in cocaine use and craving in patients with bipolar disorder (a mental disorder marked by alternating periods of mania and depression) or schizoaffective disorder/bipolar type (a psychotic disturbance in which there is a mixture of schizophrenic and manic-depressive symptoms) and cocaine abuse/dependence. This research also wants to explore if citicoline supplements are associated with greater improvement in symptoms of mania and on memory and cognition (the mental faculty of perception, reasoning, and judgement) in these patients.
A Study of the Effectiveness and Safety of Risperidone Versus Placebo in the Treatment of Manic...
Bipolar DisorderManic EpisodeThe purpose of the study is to assess the effectiveness and safety of risperidone (an antipsychotic medication) versus placebo in treating mania during 3 weeks of treatment in patients with Bipolar I Disorder who suffer from manic or mixed episodes.