
Biomarkers and Knee Osteoarthritis
Knee OsteoarthritisHigh joint load during walking has been linked to cartilage degradation. Biomarkers, found in the blood and urine, are protein fragments released after cartilage degradation characteristic of OA. They have the potential to enable direct and immediate disease state monitoring and identification of early cartilage changes. Little is known about the association of biomarkers with joint load or if exercise aimed at reducing joint load changes biomarker levels, thus reducing the risk of OA progression. This study will provide novel information on these relationships and will guide future intervention studies. The investigators hypothesize that certain biomarkers will be highly correlated with joint loading during walking and that the levels of these biomarkers in the blood and urine will decrease following an exercise intervention aimed at cartilage unloading.

Complex Āyurvedic Treatment in Osteoarthritis of the Knee Compared to Standard Care.
OsteoarthritisThe aim of this study is to evaluate the effectiveness of a complex āyurvedic diagnosis and treatment compared to conventional standard care in patients with OA of the knee.

A Study for Moderate Osteoarthritis of the Knee
OsteoarthritisThis is a study to determine whether Flexsure is Safe, Tolerable and Effective in relieving symptoms of Moderate Osteoarthritis of the Knee.

Allogeneic Mesenchymal Stem Cells for Osteoarthritis
Osteoarthritis of Knee JointThis study is designed to know the safety and efficacy of 2 different doses of mesenchymal stem cells in patients suffering from osteoarthritis of knee joint.

Autologous Adipose Tissue Derived Mesenchymal Stem Cells Therapy for Patients With Knee Osteoarthritis...
Knee OsteoarthritisTwo injections in total and 3 ml autologous adipose-tissue-derived stem cells(haMSCs) for each injection; time-points for intervention: 1) initial injection; 2) 3 weeks following initial injection.

The Study to Evaluate Efficacy and Safety of Imotun Capsule in Osteoarthritis of the Knee
Osteoarthritis of the KneeThe purpose of this study is to evaluate efficacy and safety of Imotun capsule in osteoarthritis of the knee

Lateral Wedge Insole With Subtalar Strapping for Knee Osteoarthritis
OsteoarthritisThis is a clinical study to evaluate the efficacy of a lateral wedge insole with subtalar strapping in knee osteoarthritis treatment.

Corticospinal Excitability and Rehab in Knee Osteoarthritis
Knee OsteoarthritisTo determine differences in thigh muscle function in individuals with and without knee arthritis, and also determine the effectiveness of common physical therapy interventions on clinical and patient oriented outcomes.

Effects Of Native Collagen Type 2 Treatment
Knee OsteoarthritisThe aim of this study was to evaluate symptomatic efficacy of native collagen type 2 on joint pain and function and its effects on urinary biological markers related to cartilage degeneration in patients with knee osteoarthritis.

An Exploratory Study of Tramadol Hydrochloride in Patients With Osteoarthritis of the Knee or Low...
OsteoarthritisLow Back PainThe purpose of this study is to find the clinical dose range of an active ingredient of JNS013 - Tramadol hydrochloride in chronic-pain patients who cannot attain a sufficient analgesic effect from non-steroidal anti-inflammatory drugs (NSAIDs).