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Active clinical trials for "Osteoarthritis, Knee"

Results 1861-1870 of 2600

Pilot RCT Comparing Effectiveness of Two Decision Aids for Hip and Knee Osteoarthritis

Hip OsteoarthritisKnee Osteoarthritis

This pilot RCT study is to examine the comparative effectiveness of two decision aids for hip and knee osteoarthritis.

Completed6 enrollment criteria

Intra-articular Lopain (MTX-071) Phase I/IIa Study in Chronic Osteoarthritic Knee Joint Pain

OsteoarthritisKnee

Phase I/IIa study to determine the safety and clinical effects of intra-articular injections of MTX-071 (Lopain) in patients with chronic osteoarthritic knee-joint pain.

Completed24 enrollment criteria

Ibuprofen Gel or Capsaicin Cream for my Painful Knee Osteoarthritis?

OsteoarthritisKnee

Despite evidence that topical non-steroidal anti-inflammatory drugs (NSAIDs) and capsaicin are effective in osteoarthritis (OA), it is still unclear why they work for some people but not others. The investigators are undertaking an individual patient data (IPD) meta-analysis to identify responders according to patient characteristics, however, no studies report the presence of synovial hypertrophy or neuropathic-like pain. These two traits are of interest as they may be used to optimise the treatment effects of the two drugs which work via different mechanisms to reduce pain in OA. The investigators are therefore conducting this pilot n-of-1 trial series. This pilot n-of-1 trial series will investigate whether a person with OA, who has a different balance between inflammatory and neuropathic pain, shows a preference between these mechanistically different treatments. The trial will also be used to offer recommendations on the use of n-of-1 trial series for individualised (precision) medicine in OA.

Completed21 enrollment criteria

Collaborative Lifestyle Intervention Program in Knee Osteoarthritis Patients

Osteoarthritis

The Collaborative Lifestyle Intervention Program in Knee OsteoArthritis Patients (CLIP-OA) compares a novel community-based exercise and dietary weight loss program to the Arthritis Foundation's Walk with Ease intervention on improved mobility in knee osteoarthritis (OA) patients.

Completed11 enrollment criteria

Blood Flow Restriction Exercise Study

OsteoarthritisKnee

This pilot study will investigate the effects of blood flow restriction (BFR) exercise for up to 4-6 weeks prior to total knee arthroplasty (TKA) surgery in older patients to measure clinical outcomes such as strength, lower extremity function, and pain.

Completed26 enrollment criteria

Ambulatory Continuous Adductor Canal Block to Facilitate Same Day Discharge Following Total Knee...

Knee Osteoarthritis

Patients scheduled to undergo total knee arthroplasty will receive motor sparing knee blocks with continuous adductor canal block along with multimodal analgesia started pre-operatively and continued into the postoperative period. The study will evaluate the feasibility of home discharge within the first 24 hours following total knee arthroplasty. We will also evaluate the pain scores in the first 5 days following the surgery, causes of delayed discharge and any adverse events.

Completed24 enrollment criteria

Resveratrol in Knee Osteoarthritis

Knee Osteoarthritis

The purpose of this study is to determine whether resveratrol is effective in the treatment of painful knee osteoarthritis.

Completed18 enrollment criteria

An Intervention Study Evaluating the Effects of a Raspberry Leaf Extract in an Osteoarthritic Population....

OsteoarthritisKnee

A double-blind, randomized, placebo-controlled clinical study to evaluate the efficacy of raspberry extract to alleviate symptoms of osteoarthritis in the knee.

Completed31 enrollment criteria

To Assess Efficacy of Epiitalis on Knee Pain in Patients Suffering From Knee Osteoarthritis

Knee Osteoarthritis

Epiitalis is an ingredient of a currently marketed product named as Osteo-Restore, indicated for joint health.The present study is primarily planned to establish the role of Epiitalis as a single ingredient in the treatment of mild to moderate cases of knee Osteoarthritis.

Completed30 enrollment criteria

A Mindfulness Program (MBSR) in the Management of Symptomatic Hip and Knee Osteoarthritis

OsteoarthritisMindfulness1 more

Symptomatic osteoarthritis (OA) is the most common joint disease and the leading cause of disability in industrialized countries. Therapeutic approaches to prevent the development and progression of osteoarthritis are disappointing and very limited. New therapeutic alternatives seem essential to better manage his daily life. Non-drug approaches, including psycho-corporal approaches are increasingly used in the management of chronic pain. Mindfulness is a technique of attention training, which is to focus one's attention on the present moment and to examine the sensations that come to mind, how they appear, how they last time, and how they disappear. Regarding rheumatological pathologies, a Mindfulness Program (MBSR) has shown its effectiveness in chronic pain; and in particular in osteo-articular localization, such as chronic low back pain. A recent study found a correlation between a pre-disposition to mindfulness and less pain and / or better quality of life in patients with knee osteoarthritis. However, to the knowledge of investigator, no study has evaluated the effectiveness of an intervention based on a mindfulness training program as a therapeutic alternative in osteoarthritis of the knee or hip. The goal of investigator is to evaluate, using a randomized, controlled study, the effect of a mindfulness program (according to the MBSR protocol) on pain, function, psychological state and quality of life patients with knee or hip osteoarthritis

Completed15 enrollment criteria
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