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Active clinical trials for "Dystonic Disorders"

Results 101-110 of 247

Abobotulinum Toxin and Neubotulinum Toxin Injection in Cerivical Dystonia

Cervical Dystonia

A 48-Week Prospective, Double-Blinded, Randomized, Cross-over design in Multicenter Study of, 250 unit of Abobotulinum Toxin Type A (Dysport) and 50 unit of Neubotulinum Toxin Type A (Neuronox) injection for Cervical Dystonia in patient diagnosed with cervical dystonia according to clinical diagnosis. It was designed to evaluate the efficacy, safety, tolerability, quality of life and the comparesion the improvement after treatment by of Abobotulinum Toxin Type A (Dysport) injection versus Neubotulinum Toxin Type A (Neuronox)Injection.

Completed19 enrollment criteria

Clinical Trial to Compare the Safety and Efficacy of Botulax® Versus Botox® in Patients With Cervical...

Cervical Dystonia

To determine the efficacy and safety of Botulax® in treatment of cervical dystonia

Completed5 enrollment criteria

Study Comparing Short Term Efficacy of Dysport and Dysport NG to Placebo, and to Assess Efficacy...

Cervical Dystonia

The purpose of this study is to evaluate how well a new drug called Dysport NG works and how safe it is, when it is used for the treatment of cervical dystonia. Dysport NG will be compared to an approved drug called Dysport.

Completed10 enrollment criteria

Ampicillin for DYT-1 Dystonia Motor Symptoms

DYT-1Dystonia

The purpose of this study is to evaluate if the antibiotic Ampicillin is safe and tolerated in patients that have generalized dystonia caused by the DYT-1 gene mutation, as compared to patients treated with a placebo. A placebo is a pill that looks and tastes the same as the real drug, but without the active ingredient. The second objective of this study is to determine if dystonia symptoms improve while on the study drug.

Completed9 enrollment criteria

Study to Assess the Efficacy and Safety of Dysport® in Cervical Dystonia

Cervical Dystonia

The aim is to demonstrate equivalent efficacy and safety in the treatment of the two most frequent forms of cervical dystonia (predominantly rotational torticollis and predominantly laterocollis) with the standard initial dose of 500 units Dysport®. The patients will be assigned to one of the two basic types of cervical dystonia, either predominantly rotational torticollis or predominantly laterocollis on the basis of clinical examination. This will determine which therapy is to be administered, using the clearly defined, structured injection protocols.

Completed8 enrollment criteria

Dysport for the Treatment of OMD

Oral DystoniaTardive Dystonia

The purpose of this study is to study the efficacy and safety of AbobotulinumtoxinA (Dysport) for use in Oromandibular Dystonia (OMD).

Completed18 enrollment criteria

Open-Label Non-Inferiority Study Evaluating the Efficacy and Safety of Xeomin® in Subjects With...

Cervical Dystonia

This study will compare Xeomin®, a botulinum toxin medication, in shorter treatment intervals (Short Flex dosing) to the standard interval dosing (Long Flex dosing) to determine if the response to treatment is comparable in both how it works and any side effects. Xeomin® is approved by the United States Food and Drug Administration (FDA) for the treatment of cervical dystonia (CD). The use of Xeomin® is investigational in regards to shorter treatment intervals. An investigational use is one that is not approved by the FDA.

Completed2 enrollment criteria

Quantifying Musical Performance After Treatment With Myobloc in Musician's Dystonia

Focal Dystonia

This study uses a computerized method of musical instrument digital interface (MIDI) quantification of performance before and after treatment with botulinum toxin type B (Myobloc ®, Solstice Neurosciences). Myobloc is a purified and diluted form of botulinum toxin used medically to relax unwanted muscle spasms and movements. The aim of the study is to determine the feasibility of quantifying change in performance following treatment.

Completed5 enrollment criteria

Childhood Hypertonia of Central Origin: A Trial of Anticholinergic Treatment Effects

Dystonia

This study is an open-label trial of trihexyphenidyl in children with upper extremity dystonia due to cerebral palsy. It is hypothesized that trihexyphenidyl in doses up to 0.75mg/kg/day would be well-tolerated and show significant changes on the Melbourne scale of upper extremity function.

Completed15 enrollment criteria

Neuroablation Versus Neuromodulation Techniques for Treatment of Secondary Dystonia

Secondary Dystonia

The disability inflected by dystonia encouraged the development of many neurosurgical procedures. This is a prospective study included 120 patients suffering from intractable secondary dystonia. They were subjected to different neurosurgical treatments and were assessed through the follow up period

Completed2 enrollment criteria
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