Venetoclax+Azacytidine+Modified BUCY Conditioning Regimen for Acute Myeloid Leukemia and Myelodysplastic...
Allogeneic Hematopoietic Stem Cell TransplantationAcute Myeloid Leukemia1 moreThe purpose of this prospective, open-label, single-center study is to evaluate the efficacy and safety of VEN-AZA (venetoclax and azacytidine) followed by modified BUCY (busulfan and cyclophosphamide) as conditioning regimen for high-risk myelodysplastic syndrome (MDS) and high-risk or relapsed/refractory acute myeloid leukemia (AML) undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT).
Self-Management Support for Lung Cancer Patients With Cachexia
Cachexia-Anorexia SyndromeThe goal of this randomized clinical trial is to test the efficacy of self-management support based exercise combine nutrition intervention in lung cancer patient with cancer cachexia anorexia syndrome . The main question it aims to answer is: • Would exercise combine nutrition intervention improve lung cancer patients' nutrition status? Participants will make custom exercise plan and eat enough protein food after self-management support based education. And there is a comparison group: Researchers will compare comparison group to see nutrition status who receive routine health education.
Effects of Vivatlac Synbiotikum in Patients With Irritable Bowel Syndrome
Irritable Bowel SyndromeMulti-centre, randomized, double-blind, placebo-controlled trial investigating the effects of a nine-strain synbiotic (Vivatlac Synbiotikum) in IBS patients.
Structured Exercise Versus Endovascular Reconstruction in Post Thrombotic Syndrome
Post Thrombotic SyndromeThe goal of this pilot study and randomised control trial is to compare a smartphone-based exercise programme to deep venous stenting in patients with Post Thrombotic Syndrome. The main questions it aims to answer are: Is exercise as effective as stenting in these patients? What type of exercise is useful in these patients? Can exercise be used to improve the results from surgery? Participants will be split into two groups at random. They will complete a smartphone-based exercise programme or have a deep venous stent. They will do the following tests before and after. Exercise testing Calf muscle strength and function tests Ultrasound of the deep veins Quality of life questionnaires Clinical assessment of their disease They will be compared to healthy volunteers in the pilot study. Investigators will compare exercise to stenting to see if it improves symptoms in these patients. The pilot study will help decide how many patients are needed and what exercise tests will be used for the Randomised control trial.
Laser Acupuncture on Irritable Bowel Syndrome in Females
Constipation-predominant Irritable Bowel SyndromeThe aim of the study to investigate effect of laser acupuncture on constipation predominant irritable bowel syndrome in female patients
The Intervention of Obesity in Children With Prader-Willi Syndrome Using Prebiotics and Probiotics...
Prader-Willi SyndromePrader-Willi syndrome (PWS) is a rare genetic disease, with hyperappetite and severe obesity. At present, there is no effective drugs and interventions to help control the appetite of PWS patients. More and more evidence has shown that gut microbiota is closely related to obesity. Probiotics and prebiotics can improve the structure of gut microbiota, thus improve blood lipid levels and other biochemical indicators of obese people. Therefore, this study intends to explore the effectiveness and safety of probiotics and prebiotics in controlling appetite and weight gain of PWS children.
Universal CAR-T Cells (BRL-301) in Relapse or Refractory Autoimmune Diseases
Systemic Lupus Erythematosus (SLE)Sjogren's Syndrome4 moreThis is an investigator initiated trial to assess the efficacy and safety of BRL-301 in the relapse or refractory autoimmune diseases of China.
The Effect of Erythropoietin on Alveolar Fluid Clearance in Patients With Acute Respiratory Distress...
Acute Respiratory Distress SyndromeAcute respiratory distress syndrome (ARDS) is a common acute and critical disease in clinic. The clinical mortality is as high as 30%-40%. At present, there is no specific treatment. Erythropoietin (EPO), also known as erythrocyte- stimulating factor, erythropoietin, has a certain amount in normal human body, mainly synthesized by liver in infants and kidneys in adults, which can stimulate erythropoiesis. In recent years, more and more studies have shown that high-dose exogenous EPO administration has benefit effects on multi-organ protection. Therefore, we designed this prospective, double-blind, placebo-controlled trial for defecting EPO on the alveolar fluid clearance of ARDS. The study mainly answers the following questions: Does human erythropoietin accelerate the resolution of alveolar edema in ARDS? Is there any effect on hospital survival? The study will draw conclusions by comparing the control group with the experimental group.
Effect of Aerobic Training on Sleep Problems and Pulmonary Functions in Children With Down Syndrome...
Down SyndromeThe study will be conducted to determine the effect of aerobic training on sleep problems and pulmonary functions in children with Down syndrome.
Allo HSCT Using RIC and PTCy for Hematological Diseases
Acute Myelogenous LeukemiaAcute Lymphocytic Leukemia17 moreThis is a Phase II study following subjects proceeding with our Institutional non-myeloablative cyclophosphamide/ fludarabine/total body irradiation (TBI) preparative regimen followed by a related, unrelated, or partially matched family donor stem cell infusion using post-transplant cyclophosphamide (PTCy), sirolimus and MMF GVHD prophylaxis.