Post-ICU Consultation : a Time to Discuss Advance Directives (CoPRADA)
Advance DirectivesPost Intensive Care Syndrome1 moreThe aim of this study is to assess the possibility of discussing advance directives during post-intensive care consultation.
The Prevalence and Risk Factors of Irritable Bowel Syndrome Among Adults
Irritable Bowel SyndromeColonic Diseases1 moreThis is a multicenter cross-sectional study on the prevalence of Irritable Bowel Syndrome and the risk factors associated with it. The Rome IV criteria is used for diagnosing IBS. A questionnaire-guided interview will be applied to all subjects.
(LARS) Score Validation of Turkish Language
LARS - Low Anterior Resection SyndromeLong-term bowel dysfunction after resection for rectal cancer, known as low anterior resection syndrome (LARS), is observed in many patients. The LARS score was developed to measure this syndrome and its impact on quality of life in Danish patients. Recently, English and many other language versions have been validated. The aim of this study was to validate the Turkish translation of the LARS score in Turkish patients who have undergone treatment for rectal cancer.
Retrospective Chart Review Study of Korlym for the Treatment of ACTH Independent Cushing's Syndrome...
Cushing's SyndromeChart review study to collect patient data from medical charts of patients who have been treated with Korlym® for the treatment of ACTH independent adrenal Cushing's Syndrome.
Retrospective Study of IBS-D Patients Previously Receiving SBI
Diarrhoea Predominant Irritable Bowel SyndromeThis is a retrospective study designed to gather outcomes data from existing medical charts from patients who have taken EnteraGam for management of their IBS-D for at least eight weeks. Data from two study periods will be collected: (1) the time during which the Standard of Care (SOC) therapy (i.e., prescribed or over-the-counter as well as FDA-approved or non-approved agents) that is used immediately prior to prescribing EnteraGam; and (2) the time during which EnteraGam is used as therapy.
Early Detection of Pulmonary- and Pulmonary Vascular Disease in Sjögren Syndrome
Sjögren SyndromePulmonary HypertensionAccording to the literature available pulmonary hypertension is present in 12 to 23% of patients suffering from Sjögren Syndrome. However epidemiological data are based on non-invasive measurements using echocardiography. Furthermore, no data are available regarding exercise hemodynamics in those patients. This study investigates pulmonary hemodynamics at rest and during exercise in patients suffering from primary and secondary Sjögren Syndrome. Patients under suspicion for pulmonary hypertension (PH) will be offered further investigations including right heart catheterization.
Cardiometabolic Profiles of Boys With Klinefelter Syndrome
Klinefelter Syndrome47,XXY2 moreThis study plans to learn more about how to measure the way the the body's energy system works in boys with Klinefelter syndrome, including the heart, lungs, muscles, and liver. This is important to know so that investigators understand how hormones and an extra X chromosome relate to diseases such as diabetes, extra weight gain, heart disease and liver diseases.
Impact of the Metabolic Syndrome on the Incidence of Neuropathy in Obese Subjects
Metabolic SyndromeObesity1 moreThe primary purpose of this study is to discover modifiable risk factors for the development of neuropathy, specifically looking at the metabolic syndrome.
Association Between Telomere Length and Risk of Acute Coronary Syndrome
Acute Coronary SyndromeCompelling epidemiological evidence indicates that alterations length of telomere, are associated with the initiation and development of ischemic heart disease. This study was undertaken to investigate whether mtDNA copy number in peripheral blood leukocyte could be used as a risk predictor for acute coronary syndrome.
Hormonal Sensitivity in Patients With Noonan and LEOPARD Syndromes
Noonan SyndromeLEOPARD SyndromeNoonan and LEOPARD syndromes share, with variable severity, different clinical traits, notably craniofacial manifestations, cardiopathies, short stature, and juvenile cancers. The main genetic cause of these syndromes is missense mutation of the gene encoding the ubiquitous tyrosine phosphatase Shp2, found in more than half the patients with NS and in 80% of LS cases. Shp2 plays pivotal roles in development, growth, and metabolism by regulating key signalling pathways (Ras/Mitogen activated protein kinase (MAPK), Phosphoinositide-3 Kinases (PI3K)/Akt) in response to growth factors/hormones. Deregulation of these signalling pathways has been causally linked to NS and LS pathophysiology. This project aims at better understanding hormonal sensitivity abnormalities in patients with Noonan syndrome (NS) or LEOPARD syndrome (LS) caused by mutations of the tyrosine phosphatase Shp2. To reach this goal, the investigators will take advantage of different tissues (fibroblasts ± adipocytes) from patients with NS / LS compared to healthy controls. All patients will have a skin biopsy and only patients about to undergo surgery will have a adipose tissue biopsy.