Active clinical trials for "Wounds and Injuries"

The goal of this study is to examine things that make it easy or hard for OEF/OIF veterans with polytrauma to live independently or do things "on their own" at home and in the community.

The purpose of this project is to determine the effects of mild traumatic brain injury and blast exposure on the inner ear balance and central nervous systems.

A post-marketing multi-center observational study to provide data describing the safety and effectiveness of CUREXCELL™ as it is applied in a real-life setting for treatment in patients with chronic and/or refractory wounds.

The development of pneumonia and other infections is one of the most common complications of a traumatic brain injury (TBI). Prior studies have also found that patients suffering from TBI also develop immune dysfunction consistent with an immunosuppressed state shortly after the traumatic event. Specifically, it has been shown that patients with a TBI have impaired delayed type hypersensitivity (DTH), cellular immunity and humoral immunity. The humoral arm of the immune system is particularly involved in defending the host against extracellular bacteria and is primarily composed of B-cells, immunoglobulins and complement. Surgery and trauma impair the clonal expansion of antibody producing B lymphocytes causing hypogammaglobulinemia, through a mechanism involving T lymphocytes. In addition, during the systemic inflammatory process, pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-alpha), interleukin 1 (IL-1beta) and interleukin 6 (IL-6) are released. Nuclear factor kappa beta (NF-kB) is a transcriptional regulatory protein that is involved in the expression of proinflammatory cytokines and appears to act at a critical step in the transcription of many proinflammatory genes. The hypothesis of this study is that the hypogammaglobulinemia from the immune dysfunction and the induction of NF-kB from the inflammatory process are, in part, responsible for the development of pneumonia and other infectious complications identified after TBI. This study has two specific aims: The primary specific aim of this study is to determine the association between serum immunoglobulin or NF-kB levels and the development of pneumonia in patients suffering from traumatic brain injury (TBI). The secondary specific aim of this study is to determine the relative contribution of clinical variables such as APACHE II-III Score and Injury Severity Score as compared to immunological variables (serum immunoglobulins and NF-kB) to the development of pneumonia in patients suffering from TBI.

Excitatory amino acids may be involved in secondary neuronal damage after traumatic brain injury. The amount of microglia activation is an indirect measure of neuronal damage. Micorglia activation will be measured R)-[11C]PK11195 PET 1 week, 1 month and 6 months after brain injury.

Work-related musculoskeletal disorders(MSD)are very common，which account for most of the occupational compensation in U.S.A。According to the epidemiological surveys，injured sites are frequent at low back，neck and shoulder and upper extremity。Although the MSD will not threaten the lives，they result in discomfort，some cost much and decrease the productivity。There was little study in our country to reveal the risk factors of medical utilization and disabling of MSD。Therefore，we do not have well-established strategy of the assessment and treatment for the workers who can not return to work。The purposes of this study are：1、To have sequential surveys to find the prevalence，incidence and possible risk factors of work-related MSD of employees in different industries and their medical utilization and disabled conditions。2、To find the victims of work-related MSD from clinics，assess their disablement and if they return to work and to find the factors those prevent them return to work。3、To develop individualized work hardening programs for the victims who can not return to wok after treatment。The program will be established according to their injuries and their work characteristics。

This study will attempt to evaluate clinical, laboratory and radiographic parameters together to assess heir values in outcome prediction from brain injury. Patients will be followed up for a period of 6 months, following admission to ICU, to assess outcome, using the Extended Glasgow Outcome Score (GOSE). We hypothesise that it is possible to reliably predict outcome in brain injury from the current investigations we have at our disposal.

Evaluate the pharmacokinetic differences of the main metabolite 116-N1 of JT001 in subjects with mild and moderate liver function impairment and those with normal liver function, providing a basis for formulating clinical medication plans for patients with liver function impairment;

The aim of this clinical study is to show the effects of childhood traumas on emotional intelligence levels and personality beliefs in university students. The key questions it aims to answer are: Do childhood traumas have an effect on emotional intelligence levels? Do childhood traumas have an effect on personality beliefs? Do emotional intelligence levels have an effect on personality beliefs? A socio-demographic data form, childhood trauma scale, Bar-On emotional intelligence scale and personality beliefs scale will be administered to the participants. Researchers will compare Group 1 of those with childhood trauma to Group 2 of those without childhood trauma to see the impact of childhood trauma.

Retrospective review of de-identified hospital emergency room and trauma registry data and operating room case logs from April 9th through June 9th, 2016, 2017 examining outcomes as affected by a ransomware attack in a level I trauma center