Can Genetics Predict Treatment Response to a Computerized Self-help Program for Depression?
Major Depressive DisorderMood DisordersThe goal of this project is to determine whether genetic information can be used to predict response to an internet-based treatment of depression. Several studies now indicate that completing an internet-based treatment for depression, called Deprexis, can significantly improve symptoms of depression. However, not everyone improves. The purpose of this study is to determine whether genetic profile can predict who is likely to improve.
Ketamine for Depression and Suicide Risk
DepressionSuicideThe purpose of this research study was to find out if the medication known as ketamine could help the symptoms of depression. This drug is approved by the U.S. Food and Drug Administration (FDA) as an anesthetic agent; however, it is not approved for use in depression treatment. The FDA allowed the use of this drug in this research study.
Japan Unified Protocol Clinical Trial for Depressive and Anxiety Disorders (JUNP Study)
Anxiety DisordersDepressive DisordersThis study is to examine the superiority of the combined treatments of transdiagnostic cognitive-behavior therapy (Unified Protocol; UP) and Treatment-As-Usual in comparison with the waiting-list with Treatment-As-Usual in the reduction of depressive and anxiety symptoms among depressive and anxiety disorders.
A 6-Month Extension Study To The B2061032 Study To Evaluate The Safety, Tolerability, And Efficacy...
Major Depressive DisorderThis is a 6-month, open-label, flexible-dose study evaluating Desvenlafaxine Succinate Sustained-Release (DVS SR) in the Treatment of Child and Adolescent Outpatients with Major Depressive Disorder (MDD).
A Study of Ketamine in Patients With Treatment-resistant Depression
Major Depressive DisorderThe purpose of this study is to explore the optimal dose frequency of ketamine in patients with treatment-resistant depression (TRD).
Integrating Depression Services Into DM Management
Type 2 Diabetes MellitusDepressionThe goal of this proposal is to integrate depression services into improving adherence for oral hypoglycemic agents so that a single program can assist patients. The investigators hypothesized that patients in the intervention would demonstrate improved adherence to patients' oral hypoglycemic agents and antidepressants as well as improved clinical outcomes.
A Study to Measure if There is Any Difference in How the Body Breaks Down or Inactivates Either...
Major Depressive DisorderThe purpose of this study is to measure if there is any difference in how the body breaks down or inactivates either fluoxetine or LY2216684 when both of these medicines are given together. This study will look at how fluoxetine might affect LY2216684 and how giving LY2216684 might affect fluoxetine in the body. The duration of study participation in this study is approximately 36 days not including the screening appointment. This study requires 1 research unit confinement of 29 days/28 nights followed by 1 outpatient appointment. A screening appointment is required within 30 days prior to the start of the study.
Testing the Effectiveness of a Computer-based Program for Depression
Major Depressive DisorderThe purpose of this study is to determine whether completing a computer-based program alters changes how the brain processes emotional information and improves symptoms of depression.
Early Prediction of Fluoxetine Response
Major Depressive DisorderThe purpose of this study is to identify what degree of symptom changes during the early weeks could be used to predict eventual nonresponse at week 6 among depressive inpatients taking fluoxetine.
Neurofeedback as a Treatment Tool for Depression
Unipolar DepressionThe purpose of the study is to investigate whether neurofeedback delivered via functional magnetic resonance imaging signals can be used to train depressed patients to self-regulate emotion networks and whether this improves clinical symptoms.