Individual Metabolism and Physiology Signature Study (iMAPS)
Insulin Resistance, Metabolic Syndrome X, Obesity
About this trial
This is an interventional basic science trial for Insulin Resistance focused on measuring Insulin Resistance, Obesity, US Dietary Guidelines
Eligibility Criteria
Inclusion Criteria:
- Premenopausal by self-report
- Body Mass Index 25-39.9 kg/m2
- Fasting glucose ≥100 and <126 mg/dL and/or
- Oral Glucose Tolerance Test (OGTT) 2-hour glucose ≥140 and <199 mg/dL and/or
- Quantitative insulin sensitivity check index (QUICKI) score <0.315 and/or
- Homeostasis Model Assessment (HOMA) >3.67, or log HOMA >0.085 and/or
- Glycated Hemoglobin HbA1c ≥5.7 and <6.5fasting glucose ≥100 and <126 mg/dL and/or
- Fasting triglyceride concentrations >150 mg/dL and/or
- LDL cholesterol >100 mg/dL and/or
- HDL cholesterol <40 mg/dL.
Exclusion Criteria:
- BMI <25 and >39.9 kg/m2
- Presence of any metabolic diseases, by self-report
- Gastrointestinal disorders by self-report
- Presence of cancer or other serious chronic disease by self-report
- Current use of prescribed or over the counter weight loss medications
- Pregnant
- Lactating
- Current use of tobacco
- Moderate or strenuous physical activity >30 min/day, 5 or more days per week
- Weight change >5% of body weight during the previous 6 months
- Dietary restrictions that would interfere with consuming the intervention foods
Sites / Locations
- Western Human Nutrition Research Center
- Clinical Translational Science Center
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
DGA Diet Plan
NHANES Diet Plan
A nutrient-adequate, balanced diet providing energy to maintain body weight, and macronutrient composition falling within the acceptable range, as recommended by the Institute of Medicine. The foods provided in this diet will be closely aligned with food group recommendations set in the 2010 Dietary Guidelines for Americans. All foods and beverages will be provided to enrolled subjects during the intervention period.
A nutrient-adequate, balanced diet providing energy to maintain body weight, and macronutrient composition falling within the acceptable range, as recommended by the Institute of Medicine. The foods provided in this diet plan will be closely aligned with the NHANES "What We Eat In America" report. All foods and beverages will be provided to enrolled subjects during the intervention period.