Liver Health and Metabolic Function in People With Obesity
Non-Alcoholic Fatty Liver DiseaseThis project aims to determine the effect of significant weight loss on rates on hepatic fibrogenesis in people with obesity.
To Explore the Effectiveness of Jing-Si Herbal Tea Against Non-alcoholic Fatty Liver Disease
Non-alcoholic Fatty Liver DiseaseThe aim of this study is to explore the effectiveness of Jing-Si Herbal Tea on improving the Non-alcoholic fatty liver disease patients
Dietary Allowance of Methyl Donor Nutrients to Minimize Risks of Non-alcoholic Fatty Liver Progression...
Non-alcoholic Fatty Liver DiseaseInvestigate the methyl donors requirement of NAFLD patients to correct the malnutrition, lipid-toxicity, microbiota dysfunction, and metabolomics biomarkers.
Chronic Hepatitis B Patients With Concurrent MAFLD: Cohort Study and Exercise Intervention.
Chronic Hepatitis BNon-alcoholic Fatty Liver DiseaseIn Taiwan, HBV infection is endemic in the adult population. With the westernization of eating habit and lifestyle, metabolic syndrome and related non-alcoholic fatty liver diseases (NAFLD, newly proposed as metabolic dysfunction associated fatty liver diseases, MAFLD) has become another important health issue. It is therefore common to encounter subjects with concurrent MAFLD and HBV infection in HBV endemic countries. This project will study the clinical data of patients with concurrent MAFLD and HBV, and aim to explore the impact of exercise intervention on the hepatic fatty infiltration, alteration of gut microbiota and HBV replication status in this group of patients. The research strategies will include (1) improving fatty liver and metabolic syndrome in subjects with concurrent MAFLD and HBV; and (2) exploring the changes of HBV replication and intestinal microflora in patients with concurrent HBV and MAFLD after exercise intervention.
First-in-Human Study of GM-60106 in Healthy Adults and Otherwise Healthy Adults With an Increased...
Non-alcoholic SteatohepatitisThis is a Phase 1a/1b, randomised, double-blind, placebo-controlled single- and multiple-ascending dose study to evaluate the safety, tolerability, PK, and PD of GM-60106 in healthy adult male and female participants and otherwise healthy adults who have an increased BMI and markers of NAFLD.
Prevention of NAFLD in Hispanic Children
Non-Alcoholic Fatty Liver DiseaseThis is a 2 year clinical trial testing an intensive intervention to reduce dietary sugars as a means to prevent non-alcoholic fatty liver disease (NAFLD) in pre-pubertal Hispanic children.
Non-Invasive Quantification of Liver Health in NASH (N-QUAN)
NASH - Nonalcoholic SteatohepatitisTo evaluate, in patients with suspected NASH referred for liver biopsy, the diagnostic performance of CT1 at discriminating those with NAS≥4 & F≥2 from those without.
Effects of Plant Sterols and Stanols on Liver Inflammation
NASH - Nonalcoholic SteatohepatitisThis study is a randomized, placebo-controlled, double blinded pilot study to assess the effect of consuming plant sterol or plant stanol esters (3 grams/day) for 6 months on ALT concentrations in subjects with elevated ALT concentrations, i.e. who are at risk to develop NASH.
Alternate Day Fasting, Exercise, and NAFLD
Non-Alcoholic Fatty Liver DiseaseObesityApproximately 65% of obese individuals have non-alcoholic fatty liver disease (NAFLD), and this condition is strongly related to the development of insulin resistance and diabetes. Innovative lifestyle strategies to treat NAFLD are critically needed. The proposed research will demonstrate that alternate day fasting (ADF) combined with exercise is an effective non-pharmacological therapy to treat NAFLD.
The Effect of Bariatric Surgery on Hepatic Metabolism in Non-Alcoholic Fatty Liver Disease
Non-Alcoholic Fatty Liver DiseaseThe purpose of this study is to investigate the mechanisms underlying bariatric surgery-induced resolution of non-alcoholic fatty liver disease.